Sitton N G, Taggart A J, Dixon J S, Surrall K E, Bird H A
Ann Rheum Dis. 1984 Jun;43(3):444-50. doi: 10.1136/ard.43.3.444.
Circadian variation has been demonstrated in several clinical parameters used to assess disease activity in rheumatoid arthritis, but circadian variation in modern laboratory assessments has not been studied in depth. We therefore made 2-hourly measurements of plasma viscosity, C-reactive protein, total serum sulphydryl, and serum histidine on samples obtained over a 24-hour period from 6 patients with classical or definite rheumatoid arthritis. Hourly control samples were also taken from 6 normal volunteers, 3 of whom starved from 2200 h the previous night and 3 of whom ate normally. There was no significant variation in any of these laboratory measurements between 0900 and 1800 h either in patients or controls. These findings enable us to eliminate circadian variation as a source of error when using these laboratory tests in clinical trials of slow-acting anti-rheumatoid drugs.
昼夜节律变化已在用于评估类风湿性关节炎疾病活动的多个临床参数中得到证实，但现代实验室评估中的昼夜节律变化尚未得到深入研究。因此，我们对6例典型或确诊类风湿性关节炎患者在24小时内采集的样本，每2小时测量一次血浆粘度、C反应蛋白、血清总巯基和血清组氨酸。还从6名正常志愿者中每小时采集对照样本，其中3人从前一晚22:00开始禁食，3人正常饮食。无论是患者还是对照，在09:00至18:00之间，这些实验室测量值均无显著变化。这些发现使我们能够在使用这些实验室检测进行慢效抗类风湿药物的临床试验时，排除昼夜节律变化作为误差来源。
