Otabe K, Sugimoto T, Jinbo T, Honda M, Kitao S, Hayashi S, Shimizu M, Yamamoto S
Toxicology Research Laboratories, Chugai Pharmaceutical Co., Ltd., Nagano, Japan.
Vet Res Commun. 1998 Feb;22(2):77-85. doi: 10.1023/a:1006071211779.
This study was undertaken to investigate whether the level of C-reactive protein (CRP) in the serum of dogs undergoes physiological variation, using 10 normal Beagle dogs (5 males and 5 females), 1-2 years old, maintained in a healthy condition in a controlled environment. The CRP concentration in the sera collected seven times each day at intervals of approximately 3 h ranged from 0.8 to 16.4 micrograms/ml (mean 5.06 +/- 3.60) in one experiment and from 0.8 to 14.0 micrograms/ml (mean 4.50 +/- 2.80) in a second experiment. On examining the 24-h variations in the concentration of CRP in serum, neither consistent changes nor a definite pattern of circadian rhythm was detected. During 28 days observation, only very slight changes, which seemed attributable to analytical errors, were seen in any of the dogs, except one. The concentration of CRP in the serum during the 28 days ranged from 0.8 to 22.6 micrograms/ml (mean 3.65 +/- 1.40). The concentrations underwent no significant variations in individual dogs, but significant differences were found between the dogs (p < 0.01).
本研究旨在调查犬血清中C反应蛋白（CRP）水平是否会发生生理变化，研究使用了10只1至2岁的健康比格犬（5只雄性和5只雌性），它们在可控环境中保持健康状态。在一项实验中，每天约每隔3小时采集7次血清，其中CRP浓度范围为0.8至16.4微克/毫升（平均5.06±3.60），在第二项实验中范围为0.8至14.0微克/毫升（平均4.50±2.80）。在检查血清中CRP浓度的24小时变化时，未检测到一致的变化或明确的昼夜节律模式。在28天的观察期内，除一只犬外，其他犬只均仅出现了似乎归因于分析误差的非常轻微的变化。在这28天内，血清中CRP浓度范围为0.8至22.6微克/毫升（平均3.65±1.40）。各只犬的CRP浓度无显著变化，但犬只之间存在显著差异（p<0.01）。
