类风湿关节炎疾病活动的昼夜节律变化。
Circadian variation in disease activity in rheumatoid arthritis.
作者信息
Harkness J A, Richter M B, Panayi G S, Van de Pette K, Unger A, Pownall R, Geddawi M
出版信息
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):551-4. doi: 10.1136/bmj.284.6315.551.
Abstract
Disease activity in rheumatoid arthritis as measured by repeated estimation of joint pain, stiffness, articular index, and grip strength was shown to have a circadian rythm, maximal activity being seen between 0200 and 0400 and minimal activity in the early afternoon. This variation in disease activity may be related to circadian alterations in immune and inflammatory responses (such as immune complexes and neutrophil function) dependent on alterations in circulating concentrations of steroids. The circadian variation in disease activity has important implications in assessment of patients, prescription of drugs, and performance of drug trials.
摘要
通过反复评估关节疼痛、僵硬程度、关节指数和握力来衡量的类风湿性关节炎疾病活动显示出昼夜节律，最大活动出现在02:00至04:00之间，而最小活动出现在下午早些时候。疾病活动的这种变化可能与依赖于类固醇循环浓度变化的免疫和炎症反应（如免疫复合物和中性粒细胞功能）的昼夜改变有关。疾病活动的昼夜变化对患者评估、药物处方和药物试验的实施具有重要意义。
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