Turner J, Blaney R, Roy D, Odling-Smee W, Irwin G, Mackenzie G
Lancet. 1984 Aug 11;2(8398):337-9. doi: 10.1016/s0140-6736(84)92699-0.
Of 28 788 women aged 40 to 74 registered at 28 university teaching practices in greater Belfast, half were randomly selected to receive a booklet on breast self-examination from their general practitioner at the start of the study and 1 year later. The frequency of breast abnormalities was identical in both groups (0.83%) during the 2-year follow-up. Early malignant breast cancers (stages TX, TO, Tla) were significantly more frequent in the intervention group (53.6%) than in the control group (24.3%). Among women in the intervention group with malignant lesions, 2 sites, left nipple and left inner/upper quadrant, were significantly less frequently involved. These findings in relation to staging and site were confirmed by multivariate comparisons. The intervention group also had a smaller average tumour size (24.0 mm compared with 32.6 mm) due to significantly smaller benign tumours and the absence of the relationship between delay and tumour size evident in the control group.
在大贝尔法斯特地区28所大学教学诊所登记的28788名40至74岁女性中，一半被随机挑选出来，在研究开始时和1年后从她们的全科医生那里收到一本关于乳房自我检查的手册。在2年的随访期间，两组乳房异常的发生率相同（0.83%）。早期恶性乳腺癌（TX、TO、Tla期）在干预组（53.6%）中的发生率显著高于对照组（24.3%）。在干预组有恶性病变的女性中，左乳头和左内上象限这2个部位受累的频率显著较低。这些关于分期和部位的发现通过多变量比较得到了证实。由于良性肿瘤明显较小，且干预组不存在对照组中明显的延迟与肿瘤大小之间的关系，干预组的平均肿瘤大小也较小（分别为24.0毫米和32.6毫米）。
