Barsky S H, Linnoila I, Triche T J, Costa J
Hum Pathol. 1984 Sep;15(9):892-4. doi: 10.1016/s0046-8177(84)80152-5.
A primary hepatic neoplasm with histologic features suggestive of both hepatocellular carcinoma and carcinoid tumor was studied by light microscopy, electron microscopy, and immunocytochemistry. These methods revealed areas of hepatocellular carcinoma, areas of carcinoid tumor, and mixed areas within the same cell. This case provides one more example of the coexistence of carcinoma and carcinoid in the same neoplasm and thereby supports the hypothesis that a malignantly transformed stem cell can differentiate in both epithelial and amine precursor uptake and decarboxylation (APUD) directions.
通过光学显微镜、电子显微镜和免疫细胞化学方法，对一例具有提示肝细胞癌和类癌肿瘤组织学特征的原发性肝肿瘤进行了研究。这些方法揭示了肝细胞癌区域、类癌肿瘤区域以及同一细胞内的混合区域。该病例为同一肿瘤中癌与类癌共存提供了又一个实例，从而支持了恶性转化干细胞可在上皮和胺前体摄取与脱羧（APUD）两个方向分化的假说。
