Levy J A, Mitra G, Mozen M M
Lancet. 1984 Sep 29;2(8405):722-3. doi: 10.1016/s0140-6736(84)92627-8.
The ability of infectious retroviruses to withstand the procedures used for factor VIII concentration was investigated. Mouse retroviruses added to human plasma survived these procedures and remained infectious in lyophilised samples of factor VIII. Lyophilised material had to be heated at 68 degrees C for several hours before substantial quantities of infectious virus became inactivated. These findings support the possible role of retroviruses in AIDS, and indicate that factor VIII concentrates must be heated to inactivate these infectious viruses.
研究了传染性逆转录病毒耐受用于浓缩凝血因子VIII的程序的能力。添加到人类血浆中的小鼠逆转录病毒在这些程序中存活下来，并在凝血因子VIII的冻干样本中保持感染性。冻干材料必须在68摄氏度下加热数小时，大量感染性病毒才会失活。这些发现支持了逆转录病毒在艾滋病中可能发挥的作用，并表明凝血因子VIII浓缩物必须加热以灭活这些感染性病毒。
