慢性胃炎和十二指肠溃疡患儿胃窦组织中胃泌素和生长抑素的测定
Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer.
作者信息
Xie Xiao-Zhi, Zhao Zhi-Guang, Qi Dan-Si, Wang Zong-Min
机构信息
Department of Pathology, Children's Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China.
出版信息
World J Gastroenterol. 2006 Apr 14;12(14):2288-90. doi: 10.3748/wjg.v12.i14.2288.
AIM
To study the expressions of gastrin (GAS) and somatostatin (SS) in gastric antrum tissues of children with chronic gastritis and duodenal ulcer and their role in pathogenic mechanism.
METHODS
Specimens of gastric antrum mucosa from 83 children were retrospectively analyzed. Expressions of GAS and SS in gastric antrum tissues were assayed by the immunohistochemical En Vision method.
RESULTS
The expressions of GAS in chronic gastritis Hp+ group (group A), chronic gastritis Hp-group (group B), the duodenal ulcer Hp+group (group C), duodenal ulcer Hp-group (group D), and normal control group (group E) were 28.50+4.55, 19.60+2.49, 22.69+2.71, 25.33+4.76, and 18.80+2.36, respectively. The value in groups A-D was higher than that in group E. The difference was not statistically significant. The expressions of SS in groups A-E were 15.47+1.44, 17.29+2.04, 15.30+1.38, 13.11+0.93 and 12.14+1.68, respectively. The value in groups A-D was higher than that in group E. The difference was also not statistically significant.
CONCLUSION
The expressions of GAS and SS are increased in children with chronic gastritis and duodenal ulcer.
目的
研究慢性胃炎和十二指肠溃疡患儿胃窦组织中胃泌素（GAS）和生长抑素（SS）的表达及其在发病机制中的作用。
方法
回顾性分析83例儿童胃窦黏膜标本。采用免疫组织化学En Vision法检测胃窦组织中GAS和SS的表达。
结果
慢性胃炎Hp阳性组（A组）、慢性胃炎Hp阴性组（B组）、十二指肠溃疡Hp阳性组（C组）、十二指肠溃疡Hp阴性组（D组）和正常对照组（E组）的GAS表达分别为28.50+4.55、19.60+2.49、22.69+2.71、25.33+4.76和18.80+2.36。A-D组的值高于E组。差异无统计学意义。A-E组的SS表达分别为15.47+1.44、17.29+2.04、15.30+1.38、13.11+0.93和12.14+1.68。A-D组的值高于E组。差异也无统计学意义。
结论
慢性胃炎和十二指肠溃疡患儿GAS和SS的表达增加。
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