Olsen P S, Kirkegaard P, Poulsen S S, Nexø E
Gut. 1984 Nov;25(11):1234-40. doi: 10.1136/gut.25.11.1234.
The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.
本研究旨在探讨α-和β-肾上腺素能激动剂对大鼠颌下腺表皮生长因子（EGF）分泌的影响，并测试EGF肠道吸收的可能性。α-肾上腺素能激动剂使唾液中EGF浓度增加约100倍，而血清中EGF浓度未改变。给予α-肾上腺素能激动剂去甲肾上腺素后，颌下腺中EGF含量降低，这在腺体的免疫组织化学研究中得到证实。β-肾上腺素能激动剂对颌下腺EGF分泌无影响。由于去甲肾上腺素刺激且唾液可自由进入胃肠道以及空肠内输注EGF对血清中EGF浓度均无影响，因此无法证实EGF的肠道吸收。本研究表明，α-肾上腺素能激动剂刺激颌下腺EGF的外分泌，且生理量的EGF在胃肠道中不被吸收。
