Beylot J, Doutre M S, Beylot C, Lacoste D, Boyer M
Presse Med. 1984 Nov 3;13(39):2363-6.
Immunofluorescence tests in healthy skin were performed in 75 patients with hepatitis B virus diseases (group I), in 25 HBs-antigen negative patients with the same diseases (group II) and in 90 controls (group III). HB virus diseases included acute, prolonged hepatitis; chronic, persistent and active hepatitis; cirrhosis and periarteritis nodosa. The immunofluorescence test was positive (micro- or macrogranular deposits in the walls of dermal vessels of HBs-antigen associated or not with immunoglobulins and complement) in 8 patients of group I (prolonged hepatitis 1; chronic persistent hepatitis 2; chronic active hepatitis 3; periarteritis nodosa 2), 3 of whom had no clinical manifestations, and in 3 patients of group II (chronic active hepatitis 2, periarteritis nodosa 1). Although not all patients with extrahepatic HB virus disease have a skin test positive for HBs-antigen and, conversely, a positive skin test does not necessarily imply clinical manifestations, it seems that skin immunofluorescence should be systematically performed as part of immunological investigations in all diseases where the HB virus might be involved.
对75例乙型肝炎病毒疾病患者（第一组）、25例患有相同疾病但HBs抗原阴性的患者（第二组）以及90名对照者（第三组）的健康皮肤进行了免疫荧光检测。HB病毒疾病包括急性、迁延性肝炎；慢性持续性和活动性肝炎；肝硬化和结节性多动脉炎。免疫荧光检测呈阳性（在真皮血管壁出现与免疫球蛋白和补体相关或不相关的HBs抗原的微颗粒或大颗粒沉积物）的情况在第一组8例患者中出现（迁延性肝炎1例；慢性持续性肝炎2例；慢性活动性肝炎3例；结节性多动脉炎2例），其中3例无临床表现，在第二组3例患者中出现（慢性活动性肝炎2例，结节性多动脉炎1例）。虽然并非所有肝外HB病毒疾病患者的皮肤检测HBs抗原都呈阳性，反之，皮肤检测呈阳性也不一定意味着有临床表现，但似乎在所有可能涉及HB病毒的疾病的免疫学检查中，都应系统地进行皮肤免疫荧光检测。
