Trichopoulos D, MacMahon B, Sparros L, Merikas G
J Natl Cancer Inst. 1980 Jul;65(1):111-4.
Smoking histories were obtained from 79 patients with primary hepatocellular carcinoma (PHC) (of whom 40 were negative and 39 positive for serum hepatitis B surface antigen), 39 patients with liver cancer not primary in the liver (LCNP), and 204 hospitalized controls. All subjects were Caucasians of Greek nationality and residence. No significant difference in smoking habits was found between controls and either PHC patients positive for serum hepatitis B surface antigen or LCNP patients. In contrast, there was a highly significant association between smoking and PHC negative for serum hepatitis B surface antigen (P less than 10(-4)); this association was not accounted for by the greater alcohol consumption of smokers. The risk ratios were 1.3, 2.5, 3.7, and 8.4 for current smokers of 1-10, 11-20, 21-30, and 30+ cigarettes per day.
我们获取了79例原发性肝细胞癌（PHC）患者（其中40例血清乙型肝炎表面抗原阴性，39例阳性）、39例非原发性肝癌（LCNP）患者以及204例住院对照者的吸烟史。所有受试者均为希腊籍且居住在希腊的白种人。在对照者与血清乙型肝炎表面抗原阳性的PHC患者或LCNP患者之间，未发现吸烟习惯存在显著差异。相比之下，吸烟与血清乙型肝炎表面抗原阴性的PHC之间存在高度显著的关联（P小于10^(-4)）；吸烟者饮酒量较大并不能解释这种关联。对于每天分别吸1 - 10支、11 - 20支、21 - 30支和超过30支香烟的现吸烟者，风险比分别为1.3、2.5、3.7和8.4。
