Dekruyff R H, Furie R A, Siskind G W
Immunology. 1980 Jun;40(2):255-64.
A comparison was made of the effects of carrier-specific helper T-cell tolerance and carrier-specific suppressor cells on the affinity of the anti-hapten PFC produced in both a primary and secondary anti-hapten response. Carrier-specific suppressor T cells caused a striking preferential loss of high affinity PFC in the primary response, but had only a slight effect on the affinity of the anti-hapten PFC formed in the secondary response. A carrier-specific state of tolerance, induced at a dosage which was shown not to generate significant suppressor cell activity, was associated with minimal alterations in the affinity of the primary anti-hapten PFC response. Carrier specific tolerance, induced in animals which had been previously primed to the hapten on a different carrier, had little or no effect on the affinity of the PFC response.
对载体特异性辅助性T细胞耐受性和载体特异性抑制细胞在初次和二次抗半抗原反应中产生的抗半抗原PFC亲和力的影响进行了比较。载体特异性抑制性T细胞在初次反应中导致高亲和力PFC显著优先丧失，但对二次反应中形成的抗半抗原PFC亲和力只有轻微影响。在一个未显示产生显著抑制细胞活性的剂量下诱导的载体特异性耐受状态，与初次抗半抗原PFC反应亲和力的最小改变有关。在先前已在不同载体上用半抗原进行致敏的动物中诱导的载体特异性耐受，对PFC反应的亲和力几乎没有影响。
