一些关于用聚赖氨酸刺激肥大细胞释放组胺的研究。
Some studies on the release of histamine from mast cells stimulated with polylysine.
作者信息
Ennis M, Pearce F L, Weston P M
出版信息
Br J Pharmacol. 1980 Oct;70(2):329-34. doi: 10.1111/j.1476-5381.1980.tb07940.x.
Abstract
1 Polylysine is an extremely potent releaser of histamine from rat peritoneal mast cells. Isolated mesenteric mast cells of the rat also respond to the secretagogue but guinea-pig mesenteric cells are unreactive. 2 The release does not require the presence of extracellular calcium ions but shows some dependence on internal stores of the cation. 3 The effect of polylysine is blocked by extremes of temperature and by metabolic inhibitors. 4 The release is very rapid and is virtually complete within 10 s of adding the inducer. 5 The release is unaffected by the anti-allergic drug, doxantrazole, but is inhibited by theophylline and disodium cromoglycate. The latter compounds are effective in both the presence and absence of added calcium. This result is discussed in terms of the postulated effect of the drugs on calcium transport.
摘要
- 多聚赖氨酸是从大鼠腹膜肥大细胞中释放组胺的极强诱导剂。分离出的大鼠肠系膜肥大细胞也对该促分泌剂有反应，但豚鼠肠系膜细胞无反应。2. 这种释放不需要细胞外钙离子的存在，但对阳离子的内部储存有一定依赖性。3. 多聚赖氨酸的作用被极端温度和代谢抑制剂所阻断。4. 释放非常迅速，在加入诱导剂后10秒内几乎完全完成。5. 这种释放不受抗过敏药物多沙唑嗪的影响，但被茶碱和色甘酸钠抑制。后两种化合物在添加钙和不添加钙的情况下均有效。根据药物对钙转运的假定作用对这一结果进行了讨论。
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