牛腹泻冠状病毒与血凝性脑脊髓炎病毒之间的血清学关系。
Serological relation between calf diarrhea coronavirus and hemagglutinating encephalomyelitis virus.
作者信息
Sato K, Inaba Y, Matumoto M
出版信息
Arch Virol. 1980;66(2):157-9. doi: 10.1007/BF01314983.
Neutralizing (NT) and hemagglutination-inhibiting (HI) antibodies to calf diarrhea coronavirus (CDCV) and hemagglutinating encephalomyelitis virus of swine (HEV) (strain 67N) were detected in high proportions of normal adult cattle and pigs in Japan. Since comparison of NT and HI titers in the serum samples suggested in antigenic difference between the viruses, cross NT and HI tests of these viruses were carried out with antisera raised in rabbits. The homologous NT titers were markedly higher than the heterologous titers. In HI tests essentially the same results were obtained. These findings indicate the presence of a marked difference in antigenic make-up between CDCV and HEV. NT and HI tests can clearly differentiate the viruses, although there is some cross reaction.
在日本，高比例的正常成年牛和猪体内检测到了针对牛腹泻冠状病毒（CDCV）和猪血凝性脑脊髓炎病毒（HEV，67N株）的中和（NT）抗体及血凝抑制（HI）抗体。由于血清样本中NT和HI滴度的比较表明这两种病毒在抗原性上存在差异，因此用兔制备的抗血清对这些病毒进行了交叉NT和HI试验。同源NT滴度明显高于异源滴度。在HI试验中也得到了基本相同的结果。这些发现表明CDCV和HEV在抗原组成上存在显著差异。NT和HI试验能够清楚地区分这两种病毒，尽管存在一些交叉反应。
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