Pedersen N C, Ward J, Mengeling W L
Arch Virol. 1978;58(1):45-53. doi: 10.1007/BF01315534.
Utilizing the direct and indirect fluorescent antibody procedure, the antigenic relationship of the feline infectious peritonitis virus (FIPV) to 7 other human and animal coronaviruses was studied. FIPV was found to be closely related to transmissible gastroenteritis virus (TGEV) of swine. Transmissible gastroenteritis virus and FIPV were in turn antigenically related to human coronavirus 229E (HCV-229E) and canine coronavirus (CCV). An interesting finding in the study was that the 8 coronaviruses selected for this study fell into one of two antigenically distinct groups. Viruses in each group were antigenically related to each other to varying degrees, but were antigenically unrelated to coronaviruses of the second group. The first antigenically related group was comprised of mouse hepatitis virus, type 3 (MHV-3), hemeagglutinating encephalomyelitis virus 67N (HEV-67N) of swine, calf diarrhea coronavirus (CDCV), and human coronavirus 0C43 (HCV-OC43). The second antigenically related group was comprised of FIPV, TGEV, HCV-229E and CCV.
利用直接和间接荧光抗体法,研究了猫传染性腹膜炎病毒(FIPV)与其他7种人和动物冠状病毒的抗原关系。发现FIPV与猪的传染性胃肠炎病毒(TGEV)密切相关。传染性胃肠炎病毒和FIPV又与人类冠状病毒229E(HCV - 229E)和犬冠状病毒(CCV)存在抗原关系。该研究中的一个有趣发现是,本研究选取的8种冠状病毒分为两个抗原性不同的组之一。每组中的病毒彼此之间存在不同程度的抗原关系,但与第二组的冠状病毒无抗原关系。第一个抗原相关组由3型小鼠肝炎病毒(MHV - 3)、猪的血凝性脑脊髓炎病毒67N(HEV - 67N)、犊牛腹泻冠状病毒(CDCV)和人类冠状病毒0C43(HCV - OC43)组成。第二个抗原相关组由FIPV、TGEV、HCV - 229E和CCV组成。