Katz D M, Karten H J
J Comp Neurol. 1980 Sep 15;193(2):549-64. doi: 10.1002/cne.901930216.
The distribution of Substance P-like immunoreactivity in the jugular and nodose ganglia of rabbits and pigeons has been studied using immunocytochemical staining techniques. Substance P-like immunoreactivity is localized to neuronal cell bodies and processes in the jugular and nodose ganglia, and to pericellular fiber plexi in the nodose ganglia of both species. The numbers and sizes of cells which exhibited Substance P-like immunoreactivity in each ganglion were determined using quantitative morphometric techniques. The distribution of Substance P-like immunoreactivity in the rabbit and pigeon vagal sensory ganglia is characterized by several general features. In most of the ganglia, immunoreactive neurons factor into discrete types which can be distinguished from one another, and from non-immunoreactive neurons, by size. In addition, immunoreactive nodose and jugular ganglion cells, respectively, are distinguishable on the basis of size. Finally, a considerably high percentage of immunoreactive neurons is found in the jugular ganglion than in the nodose ganglion. Substance P-like immunoreactivity was also seen in pericellular fiber plexi which encircle individual neurons in the nodose ganglion of rabbits and pigeons. These plexi are composed of varicose fibers which appear to terminate as boutons on the surface of the cells which they encircle. The distribution of Substance P-like immunoreactivity within the vagal sensory ganglia is discussed with respect to the possible peripheral targets and functions of Substance P-containing vagal afferents. Our findings suggest that Substance P-containing vagal sensory neurons are involved in a variety of visceral and somatic afferent functions.
运用免疫细胞化学染色技术，对家兔和鸽子颈静脉神经节及结状神经节中P物质样免疫反应性的分布进行了研究。P物质样免疫反应性定位于颈静脉神经节和结状神经节中的神经元细胞体和突起，以及两种动物结状神经节中的细胞周纤维丛。采用定量形态测量技术确定了每个神经节中呈现P物质样免疫反应性的细胞数量和大小。家兔和鸽子迷走神经感觉神经节中P物质样免疫反应性的分布具有几个一般特征。在大多数神经节中，免疫反应性神经元可分为不同类型，这些类型可通过大小与彼此以及非免疫反应性神经元区分开来。此外，免疫反应性结状神经节细胞和颈静脉神经节细胞分别可根据大小区分。最后，发现颈静脉神经节中免疫反应性神经元的百分比比结状神经节中的高得多。在环绕家兔和鸽子结状神经节中单个神经元的细胞周纤维丛中也可见到P物质样免疫反应性。这些纤维丛由曲张纤维组成，这些曲张纤维似乎在它们所环绕的细胞表面以终扣的形式终止。就含P物质的迷走传入神经可能的外周靶点和功能，讨论了迷走感觉神经节内P物质样免疫反应性的分布。我们的研究结果表明，含P物质的迷走感觉神经元参与多种内脏和躯体传入功能。
