Whittaker D K
J Oral Pathol. 1980 Jul;9(4):235-45. doi: 10.1111/j.1600-0714.1980.tb00381.x.
Mitotic activity in the basal epithelial cells and mast cell degranulation have been studied as markers of early cellular change following experimental cryosurgery of hamster sublingual epithelium. It has been shown that mitotic activity initially increases, suggesting that freezing is a stimulus to cell division. Within a short time mitotic activity rapidly falls and this fall is preceded by a marked fall in the number of intact mast cells in the tissue. The timing of both events supports the view that early damage is apparent before vascular stasis intervenes.
作为仓鼠舌下上皮实验性冷冻手术后早期细胞变化的标志物，已对基底上皮细胞的有丝分裂活性和肥大细胞脱颗粒进行了研究。结果表明，有丝分裂活性最初会增加，这表明冷冻是细胞分裂的一种刺激因素。在短时间内，有丝分裂活性迅速下降，而这种下降之前组织中完整肥大细胞的数量会显著减少。这两个事件的时间安排支持了这样一种观点，即在血管淤滞介入之前，早期损伤就已明显。
