人类Ia分子的免疫学剖析
Immunological dissection of human Ia molecules.
作者信息
Tosi R, Tanigaki N, Centis D, Ferrara G B, Pressman D
出版信息
J Exp Med. 1978 Dec 1;148(6):1592-611. doi: 10.1084/jem.148.6.1592.
Abstract
The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.
摘要
运用多种同种异体抗血清对Daudi Ia分子进行免疫化学分析，结果发现至少有三种携带不同抗原决定簇的分子类型：DRw6、DC-1和DC-2。遗传学及结构学证据表明，DRw6和DC-1分子由不同的、与HLA连锁的基因座控制，而非由同一基因座上的等位基因控制。同种异体抗原决定簇似乎在小Ia亚基上表达。所讨论的DC-1和DC-2决定簇在群体水平上尚未通过血清学分析得以界定，但在分子水平上通过免疫化学分析证实它们是存在的。
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