来自淋巴细胞的普遍存在的非免疫球蛋白对氨基苯砷酸结合分子。
Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells.
作者信息
Clark A F, Capra J D
出版信息
J Exp Med. 1982 Feb 1;155(2):611-6. doi: 10.1084/jem.155.2.611.
Abstract
A ubiquitous nonimmunoglobulin molecule that binds p-azobenzenearsonate (ABA) has been detected in the cytoplasm of several murine cell lines, including T cell hybridomas as well as in normal liver and spleen. Similar to many recently described antigen-specific T cell factors, this ABA-binding protein has a 62,000 mol wt, and, when analyzed by direct binding, the molecule reacts with several different rabbit anti-idiotypic antisera specific to the ABA system. The presence of this antigen-specific, "idiotype positive" molecule in many different cells indicates that it is not an important immunoregulatory molecule.
摘要
在几种小鼠细胞系的细胞质中，包括T细胞杂交瘤以及正常肝脏和脾脏中，检测到一种能结合对氨基苯砷酸（ABA）的普遍存在的非免疫球蛋白分子。与许多最近描述的抗原特异性T细胞因子相似，这种ABA结合蛋白的分子量为62,000道尔顿，通过直接结合分析，该分子能与几种针对ABA系统的不同兔抗独特型抗血清发生反应。这种抗原特异性的“独特型阳性”分子在许多不同细胞中的存在表明它不是一种重要的免疫调节分子。
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本文引用的文献
1
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J Exp Med. 1980 Oct 1;152(4):893-904. doi: 10.1084/jem.152.4.893.
2
Functional association of idiotypic and I-J determinants on the antigen receptor of suppressor T cells.抑制性T细胞抗原受体上独特型与I-J决定簇的功能关联。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4557-61. doi: 10.1073/pnas.78.7.4557.
3
Cross-reactivity between C-reactive protein and idiotypic determinants on A phosphocholine-binding murine myeloma protein.C反应蛋白与一种磷酸胆碱结合型小鼠骨髓瘤蛋白上的独特型决定簇之间的交叉反应性。
J Exp Med. 1981 Jun 1;153(6):1604-14. doi: 10.1084/jem.153.6.1604.
4
Antigen-specific T lymphocyte clones. II. Purification and biological characterization of an antigen-specific suppressive protein synthesized by cloned T cells.抗原特异性T淋巴细胞克隆。II. 克隆T细胞合成的抗原特异性抑制蛋白的纯化及生物学特性
J Exp Med. 1981 May 1;153(5):1260-74. doi: 10.1084/jem.153.5.1260.
5
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6
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9
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