抗原特异性T细胞因子对抗体应答抑制作用的细胞后果
Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor.
作者信息
Taniguchi M, Tokuhisa T
出版信息
J Exp Med. 1980 Mar 1;151(3):517-27. doi: 10.1084/jem.151.3.517.
Abstract
Cellular events mediated by antigen-specific soluble factor extracted from carrier-primed suppressor T cells (TsF) in the suppressive interaction was studied. Keyhole limpet hemocyanin (KLH)-specific TsF directly acts on KLH-primed, I-J positive, nylon-wool-adherent T cells that have an acceptor site for TsF. The nylon-wool-adherent T cells, after accepting TsF in the presence of specific antigen, generate new suppressor T cells acting as an actual effector cell type. Antigen-specificity and syngeneity at I-J between TsF and acceptor T cells are both required for the induction of new suppressor T cells. Newly induced suppressor T cells, however, suppress both syngeneic and allogeneic responses in an antigen-nonspecific fashion.
摘要
研究了在抑制性相互作用中，由载体致敏抑制性T细胞（TsF）提取的抗原特异性可溶性因子介导的细胞事件。钥孔戚血蓝蛋白（KLH）特异性TsF直接作用于已用KLH致敏、I-J阳性、尼龙毛黏附的T细胞，这些T细胞具有TsF的受体位点。尼龙毛黏附的T细胞在存在特异性抗原的情况下接受TsF后，会产生作为实际效应细胞类型的新的抑制性T细胞。TsF与受体T细胞之间在I-J处的抗原特异性和同基因性对于新的抑制性T细胞的诱导都是必需的。然而，新诱导的抑制性T细胞以抗原非特异性方式抑制同基因和异基因反应。
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