Overall J C, Yeh T J, Kern E R
J Infect Dis. 1980 Dec;142(6):943. doi: 10.1093/infdis/142.6.943.
Ten isolates of herpes simplex virus (HSV) type 1 and nine isolates of HSV type 2 were tested against virus-induced (alpha), fibroblast (beta), and mitogen-induced (gamma) preparations of human interferon (HuIFN). HSV type 2 was slightly more sensitive and HSV type 1 somewhat less sensitive to all three preparations of HuIFN than Sindbis and vesicular stomatitis virus-both considered to be quite sensitive to HuIFN. HSV type 2 was significantly more sensitive than HSV type 1 to each of the HuIFN preparations (P less than 0.01; Mann-Whitney ranksum test). Clinical isolates did not appear to differ from laboratory strains. These results indicate that both HSV types 1 and 1 are sensitive to the three different preparations of HuIFN. HuIFN may have a role in natural recovery from and may have potential as an antriviral chemotherapeutic agent in HSV infections in humans.
对10株1型单纯疱疹病毒（HSV）和9株2型HSV进行了检测，观察它们对病毒诱导的（α）、成纤维细胞的（β）以及丝裂原诱导的（γ）人干扰素（HuIFN）制剂的反应。与辛德毕斯病毒和水疱性口炎病毒相比，2型HSV对所有三种HuIFN制剂的敏感性略高，而1型HSV的敏感性略低，辛德毕斯病毒和水疱性口炎病毒都被认为对HuIFN相当敏感。2型HSV对每种HuIFN制剂的敏感性均显著高于1型HSV（P＜0.01；曼-惠特尼秩和检验）。临床分离株似乎与实验室菌株没有差异。这些结果表明，1型和2型HSV对三种不同的HuIFN制剂均敏感。HuIFN可能在人类HSV感染的自然恢复过程中发挥作用，并且有可能作为一种抗病毒化疗药物。
