衰老过程中的RNA代谢（作者译）

[RNA-metabolism in aging (author's transl)].

作者信息

Martin H, Martin R

出版信息

Z Alternsforsch. 1980;35(1):13-9.

Abstract

After intraperitoneal application of 14C-orotic acid the tracer distribution and the labelling of total RNA in different organs of two groups of Wistar rats (5 and 22,5 months old) were represented. After 60 min 2/3 of tracer were found in liver and kidney. The uptake by liver of old animals is decreased significantly. The interactions between the tracer distribution in the organism, the time related uptake by the organs, the organ function (influenced by methimazol) and the specific activity of RNA were represented. From the results the conclusion is drawn that the comparison of the specific activities of total RNA alone--especially in comparison of young with old animals--is not sufficient for the examination of RNA synthesis.

摘要

在向两组Wistar大鼠（5个月和22.5个月大）腹腔注射14C-乳清酸后，展示了示踪剂分布以及不同器官中总RNA的标记情况。60分钟后，2/3的示踪剂出现在肝脏和肾脏中。老年动物肝脏对示踪剂的摄取显著降低。展示了示踪剂在生物体内的分布、各器官随时间的摄取、器官功能（受甲巯咪唑影响）与RNA比活性之间的相互关系。从结果得出结论，仅比较总RNA的比活性——尤其是在年轻动物与老年动物之间进行比较——对于RNA合成的检测是不够的。

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