多发性硬化症中的麻疹抗体与组织相容性类型

Measles antibodies and histocompatibility types in multiple sclerosis.

作者信息

Fewster M E, Ames F R, Botha M C

出版信息

J Neurol Sci. 1979 Sep;43(1):19-26. doi: 10.1016/0022-510x(79)90070-4.

Abstract

Measles antibody titres and HLA antigens were determined in 71 White and 11 Coloured multiple sclerosis (MS) patients and 71 White and 11 Coloured age and sex-matched controls. Measles antibody titres were determined by the hemagglutination inhibition test and HLA antigens were determined serologically by a micro-lymphocytotoxicity test. Measles antibody titres were significantly higher in MS than in control cases and this was true for both female and male patients. No association was observed between the HLA antigens, especially HLA-A3 or HLA-B7 and measles antibody titres in the sera of MS patients or controls.

摘要

对71名白人及11名有色人种的多发性硬化症（MS）患者以及71名白人及11名有色人种的年龄和性别匹配的对照者测定了麻疹抗体滴度和HLA抗原。通过血凝抑制试验测定麻疹抗体滴度，通过微量淋巴细胞毒性试验血清学测定HLA抗原。MS患者的麻疹抗体滴度显著高于对照病例，男女患者均如此。在MS患者或对照者血清中，未观察到HLA抗原尤其是HLA - A3或HLA - B7与麻疹抗体滴度之间存在关联。