经电泳纯化的小鼠干扰素可抑制生长、诱发肝肾损伤并杀死乳鼠。
Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
作者信息
Gresser I, Aguet M, Morel-Maroger L, Woodrow D, Puvion-Dutilleul F, Guillon J C, Maury C
出版信息
Am J Pathol. 1981 Mar;102(3):396-402.
Abstract
Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.
摘要
给哺乳期的瑞士小鼠每日注射电泳纯（EP）小鼠干扰素（比活性为4.7×10⁸单位/毫克蛋白质）、纯化过程中获得的主要杂质或部分纯化的小鼠干扰素（比活性为1.3×10⁷单位/毫克蛋白质），持续8天。只有EP或部分纯化的干扰素能抑制生长、诱发肝肾损伤并导致小鼠死亡。作者得出结论，这些效应是由干扰素本身引起的。
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