Kuo T
Am J Surg Pathol. 1980 Dec;4(6):573-83. doi: 10.1097/00000478-198012000-00008.
Certain clear-cell carcinomas of the skin observed in elderly caucasian men with a history of excessive sun exposure and multiple skin neoplasms may be mistaken for sebaceous carcinomas or other cutaneous clear-cell tumors. These tumors are believed to be variants of squamous cell carcinoma undergoing extensive hydropic change which results in the clear-cell appearance. They are classified into three histologic types. Type I and type III tumors are either primary or recurrent squamous-cell carcinomas. The histogenesis of type II tumors is uncertain but they may represent recurrent metastatic tumors from the previously excised, adjacent epidermal squamous-cell carcinomas; however, the possibility that they are primary adnexal tumors of undetermined histogenesis remains to be determined. Various techniques of staining, as well as differences in histologic appearance, assist in the differential diagnosis of these and other cutaneous clear-cell neoplasms.
在有过度日晒史和多发皮肤肿瘤的老年白种男性中观察到的某些皮肤透明细胞癌，可能会被误诊为皮脂腺癌或其他皮肤透明细胞肿瘤。这些肿瘤被认为是经历广泛水样变性的鳞状细胞癌变体，从而导致透明细胞外观。它们分为三种组织学类型。I型和III型肿瘤要么是原发性鳞状细胞癌，要么是复发性鳞状细胞癌。II型肿瘤的组织发生尚不确定，但它们可能代表来自先前切除的相邻表皮鳞状细胞癌的复发性转移瘤；然而，它们是组织发生未明的原发性附属器肿瘤的可能性仍有待确定。各种染色技术以及组织学外观的差异有助于对这些及其他皮肤透明细胞肿瘤进行鉴别诊断。
