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β2微球蛋白与异种血清的结合。

Binding of beta 2-microglobulin by heterologous sera.

作者信息

Lögdberg L, Cigén R, Björck L

出版信息

Scand J Immunol. 1981;13(3):237-43. doi: 10.1111/j.1365-3083.1981.tb00131.x.

DOI:10.1111/j.1365-3083.1981.tb00131.x
PMID:6165075
Abstract

Purified human, rat or guinea-pig beta 2-microglobulin (beta 2m) was mixed with sera from guinea-pig, rat, mouse, rabbit, horse, goat, cow, rhesus monkey or man. The mixtures were incubated at 37 degrees C for various lengths of time. When the sera were separated by gel-chromatography on Sephadex G-200, beta 2m was traced not only in 'free' form but also in fractions with higher molecular weights. Evidence is presented suggesting that heterologous beta 2m binds to beta 2m-containing molecules in sera by exchange with the homologous counterpart.

摘要

将纯化的人、大鼠或豚鼠β2-微球蛋白(β2m)与豚鼠、大鼠、小鼠、兔、马、山羊、牛、恒河猴或人的血清混合。混合物在37℃孵育不同时间。当通过Sephadex G-200凝胶色谱分离血清时,β2m不仅以“游离”形式被检测到,还在高分子量组分中被检测到。有证据表明,异源β2m通过与同源对应物交换,与血清中含β2m的分子结合。

相似文献

1
Binding of beta 2-microglobulin by heterologous sera.β2微球蛋白与异种血清的结合。
Scand J Immunol. 1981;13(3):237-43. doi: 10.1111/j.1365-3083.1981.tb00131.x.
2
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3
Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.抗原特异性辅助因子可与人β2微球蛋白抗体发生反应。
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Effects of anti-guinea-pig beta 2-microgloblin antibodies on lymphocyte transformation induced by specific antigens or mitogens.抗豚鼠β2-微球蛋白抗体对特定抗原或有丝分裂原诱导的淋巴细胞转化的影响。
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Immunological analysis of alpha 1-microglobulin in different mammalian and chicken serum. alpha 1-Microglobulin is 5-8 kilodaltons larger in primates.不同哺乳动物和鸡血清中α1-微球蛋白的免疫学分析。α1-微球蛋白在灵长类动物中比其他动物大5 - 8千道尔顿。
J Biol Chem. 1985 Apr 25;260(8):4839-44.

引用本文的文献

1
beta 2-Microglobulin secretion from lymphoid cells: a study at the cellular level.淋巴细胞分泌β2-微球蛋白:细胞水平的研究
Med Microbiol Immunol. 1985;174(2):59-66. doi: 10.1007/BF02123226.
2
Three-dimensional structure of beta 2-microglobulin.β2-微球蛋白的三维结构。
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4225-9. doi: 10.1073/pnas.82.12.4225.
3
A soluble class I molecule analogous to mouse Q10 in the horse and related species.
Immunogenetics. 1986;23(5):277-83. doi: 10.1007/BF00398789.
4
A deletion in a rat major histocompatibility complex class I gene is linked to the absence of beta 2-microglobulin-containing serum molecules.大鼠主要组织相容性复合体I类基因的一个缺失与不含β2-微球蛋白的血清分子的缺失有关。
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5630-3. doi: 10.1073/pnas.83.15.5630.