T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.
作者信息
Andersson J, Schreier M H, Melchers F
出版信息
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
Cloned lines of helper thymus-derived (T) cells produce help for bone marrow-derived (B) cell growth and Ig secretion in the presence of histocompatible adherent cells and of specific antigen. This help stimulates histocompatible as well as histoincompatible B-cell blasts polyclonally. Thus, neither antigen nor histocompatibility, but antigen-unspecific factor(s) for growth and Ig secretion are required to stimulate a B-cell blast through the next round of division. On the other hand, only histocompatible, resting, small B cells, and only those binding their specific antigen, can be stimulated by antigen-activated T-cell help to initiate growth and Ig secretion. The preference of the resting B cells for such collaboration with T-cell help is mapped to the K end of the H-2 histocompatibility locus, and probably constitutes the antigen expressed on B cells by the immune response (I) region. It appears that a resting B cell is excited by the binding of specific antigen to surface Ig and by the interaction of its surface Ia antigen with helper T cells. After this dual recognition the excited B cell can be stimulated by the antigen-unspecific factor(s) generated by the interaction of helper T-cells, adherent cells, and antigen to initiate replication.
克隆的辅助性胸腺来源（T）细胞系在存在组织相容性贴壁细胞和特定抗原的情况下，为骨髓来源（B）细胞的生长和免疫球蛋白分泌提供辅助。这种辅助多克隆地刺激组织相容性以及组织不相容性的B细胞母细胞。因此，刺激B细胞母细胞进入下一轮分裂并不需要抗原或组织相容性，而是需要生长和免疫球蛋白分泌的抗原非特异性因子。另一方面，只有组织相容性的、静止的、小B细胞，而且只有那些结合其特定抗原的小B细胞，才能被抗原激活的T细胞辅助刺激而启动生长和免疫球蛋白分泌。静止B细胞对与T细胞辅助进行这种协作的偏好定位于H-2组织相容性基因座的K端，并且可能构成由免疫反应（I）区在B细胞上表达的抗原。似乎静止B细胞通过特异性抗原与表面免疫球蛋白的结合以及其表面Ia抗原与辅助性T细胞的相互作用而被激活。在这种双重识别之后，被激活的B细胞可以被辅助性T细胞、贴壁细胞和抗原相互作用产生的抗原非特异性因子刺激而启动复制。
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