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1
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
2
Cellular interaction and the environment in lymphocyte development: the roles of antigen, histocompatibility, and growth factors in T cell-dependent B cell stimulation.淋巴细胞发育中的细胞相互作用与环境：抗原、组织相容性和生长因子在T细胞依赖性B细胞刺激中的作用。
Prog Clin Biol Res. 1981;66 Pt A:579-88.
3
T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.静止B细胞的T细胞依赖性激活：对非特异性无限制和抗原特异性Ia限制可溶性因子的需求。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2497-501. doi: 10.1073/pnas.78.4.2497.
4
Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes.主要组织相容性复合体限制的多克隆B细胞应答，由辅助性T细胞识别小B淋巴细胞呈递的抗免疫球蛋白所致。
J Exp Med. 1985 Jan 1;161(1):223-41. doi: 10.1084/jem.161.1.223.
5
Dissociation of two signals required for activation of resting B cells.静止B细胞激活所需的两种信号的解离。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1989-93. doi: 10.1073/pnas.79.6.1989.
6
Characterization of the effector mechanism of help for antigen-presenting and bystander resting B cell growth mediated by Ia-restricted Th2 helper T cell lines.Ia 限制的 Th2 辅助性 T 细胞系介导的对抗抗原呈递和旁观者静止 B 细胞生长的辅助效应机制的表征。
J Immunol. 1988 Oct 1;141(7):2230-9.
7
Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.在经辐照的亲代品系小鼠中对异源红细胞进行阳性选择的F1杂种T细胞的受限辅助功能。II. 影响辅助细胞诱导和T-B协作的限制证据，二者均定位于H-2复合体的K端。
J Exp Med. 1978 Apr 1;147(4):1159-74. doi: 10.1084/jem.147.4.1159.
8
In vitro analysis of allogeneic lymphocyte interaction. VIII. Characterization of helper components of allogeneic effect factor (AEF) that activate Lyb5+ and Lyb5- B cells to respond to thymus-dependent and thymus-independent antigens.同种异体淋巴细胞相互作用的体外分析。VIII. 激活Lyb5 +和Lyb5 - B细胞以响应胸腺依赖性和胸腺非依赖性抗原的同种异体效应因子（AEF）辅助成分的特征。
J Immunol. 1983 Nov;131(5):2246-53.
9
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
10
T cell-dependent B cell activation.T细胞依赖性B细胞活化
Annu Rev Immunol. 1993;11:331-60. doi: 10.1146/annurev.iy.11.040193.001555.

引用本文的文献

1
Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III.迈向对适应性免疫的分子理解：年表，第三部分。
Front Immunol. 2014 Feb 4;5:29. doi: 10.3389/fimmu.2014.00029. eCollection 2014.
2
Humoral immune responses in CD40 ligand-deficient mice.CD40配体缺陷小鼠中的体液免疫反应。
J Exp Med. 1994 Nov 1;180(5):1889-900. doi: 10.1084/jem.180.5.1889.
3
The biology of the human ligand for CD40.CD40的人类配体生物学
J Clin Immunol. 1993 Nov;13(6):373-80. doi: 10.1007/BF00920012.
4
T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.T细胞衍生的B细胞分化因子。对小鼠B细胞同种型转换的影响。
J Exp Med. 1982 Mar 1;155(3):734-48. doi: 10.1084/jem.155.3.734.
5
Antigen-specific human T-cell hybridomas with helper activity.具有辅助活性的抗原特异性人T细胞杂交瘤。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6646-50. doi: 10.1073/pnas.79.21.6646.
6
Requirement for three signals in B cell responses. II. Analysis of antigen- and Ia-restricted T helper cell-B cell interaction.B细胞应答中三种信号的需求。II. 对抗原及Ia限制的辅助性T细胞与B细胞相互作用的分析。
J Exp Med. 1982 Aug 1;156(2):415-29. doi: 10.1084/jem.156.2.415.
7
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性
Immunology. 1982 Jul;46(3):575-81.
8
Dissociation of two signals required for activation of resting B cells.静止B细胞激活所需的两种信号的解离。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1989-93. doi: 10.1073/pnas.79.6.1989.
9
T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.T淋巴细胞依赖性B淋巴细胞对抗原的增殖反应。I. B淋巴细胞增殖刺激的遗传限制
J Exp Med. 1981 Apr 1;153(4):871-82. doi: 10.1084/jem.153.4.871.
10
Genetic control of immune response to myoglobin. Ir gene function in genetic restriction between T and B lymphocytes.对肌红蛋白免疫反应的遗传控制。Ir基因在T淋巴细胞和B淋巴细胞之间遗传限制中的功能。
J Exp Med. 1982 Nov 1;156(5):1486-501. doi: 10.1084/jem.156.5.1486.

本文引用的文献

1
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
2
Separation of cells by velocity sedimentation.通过速度沉降法分离细胞。
J Cell Physiol. 1969 Jun;73(3):191-201. doi: 10.1002/jcp.1040730305.
3
Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin.体外溶血素反应的诱导。骨髓来源细胞与胸腺来源细胞的相互作用。
J Exp Med. 1970 Dec 1;132(6):1267-78. doi: 10.1084/jem.132.6.1267.
4
Letter: T cell-dependent mediator in the immune response.信件：免疫反应中T细胞依赖性介质。
Nature. 1973 Jun 8;243(5406):356-7. doi: 10.1038/243356a0.
5
Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.体外T和B淋巴细胞的激活。II. 一种在触发特异性B淋巴细胞中起作用的同种异体效应因子（AEF）的生物学和生化特性。
J Exp Med. 1974 Jul 1;140(1):19-37. doi: 10.1084/jem.140.1.19.
6
Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
J Exp Med. 1973 Nov 1;138(5):1194-212. doi: 10.1084/jem.138.5.1194.
7
Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。H-2基因复合体决定淋巴细胞间成功的生理相互作用。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2624-8. doi: 10.1073/pnas.70.9.2624.
8
A plaque assay for all cells secreting Ig of a given type or class.针对所有分泌特定类型或类别的免疫球蛋白的细胞进行的噬斑测定。
Eur J Immunol. 1976 Aug;6(8):588-90. doi: 10.1002/eji.1830060812.
9
Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice.未致敏、A 群链球菌碳水化合物致敏、抗 A5A 独特型致敏及抗 A5A 独特型抑制的 A/J 小鼠中产生 A5A 独特型的脂多糖反应性 B 细胞的绝对频率。
J Exp Med. 1977 Nov 1;146(5):1436-49. doi: 10.1084/jem.146.5.1436.
10
Frequencies of mitogen-reactive B cells in the mouse. II. Frequencies of B cells producing antibodies which lyse sheep or horse erythrocytes, and trinitrophenylated or nitroiodophenylated sheep erythrocytes.小鼠中有丝分裂原反应性B细胞的频率。II. 产生能裂解绵羊或马红细胞以及三硝基苯基化或硝基碘苯基化绵羊红细胞的抗体的B细胞频率。
J Exp Med. 1977 Jun 1;145(6):1520-30. doi: 10.1084/jem.145.6.1520.

T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。

T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.

作者信息

Andersson J, Schreier M H, Melchers F

出版信息

Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.

DOI:10.1073/pnas.77.3.1612
PMID:6966402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC348547/
Abstract

Cloned lines of helper thymus-derived (T) cells produce help for bone marrow-derived (B) cell growth and Ig secretion in the presence of histocompatible adherent cells and of specific antigen. This help stimulates histocompatible as well as histoincompatible B-cell blasts polyclonally. Thus, neither antigen nor histocompatibility, but antigen-unspecific factor(s) for growth and Ig secretion are required to stimulate a B-cell blast through the next round of division. On the other hand, only histocompatible, resting, small B cells, and only those binding their specific antigen, can be stimulated by antigen-activated T-cell help to initiate growth and Ig secretion. The preference of the resting B cells for such collaboration with T-cell help is mapped to the K end of the H-2 histocompatibility locus, and probably constitutes the antigen expressed on B cells by the immune response (I) region. It appears that a resting B cell is excited by the binding of specific antigen to surface Ig and by the interaction of its surface Ia antigen with helper T cells. After this dual recognition the excited B cell can be stimulated by the antigen-unspecific factor(s) generated by the interaction of helper T-cells, adherent cells, and antigen to initiate replication.

摘要

克隆的辅助性胸腺来源（T）细胞系在存在组织相容性贴壁细胞和特定抗原的情况下，为骨髓来源（B）细胞的生长和免疫球蛋白分泌提供辅助。这种辅助多克隆地刺激组织相容性以及组织不相容性的B细胞母细胞。因此，刺激B细胞母细胞进入下一轮分裂并不需要抗原或组织相容性，而是需要生长和免疫球蛋白分泌的抗原非特异性因子。另一方面，只有组织相容性的、静止的、小B细胞，而且只有那些结合其特定抗原的小B细胞，才能被抗原激活的T细胞辅助刺激而启动生长和免疫球蛋白分泌。静止B细胞对与T细胞辅助进行这种协作的偏好定位于H-2组织相容性基因座的K端，并且可能构成由免疫反应（I）区在B细胞上表达的抗原。似乎静止B细胞通过特异性抗原与表面免疫球蛋白的结合以及其表面Ia抗原与辅助性T细胞的相互作用而被激活。在这种双重识别之后，被激活的B细胞可以被辅助性T细胞、贴壁细胞和抗原相互作用产生的抗原非特异性因子刺激而启动复制。