Metter E J, Riege W H, Hanson W R, Camras L R, Phelps M E, Kuhl D E
Brain Lang. 1984 Mar;21(2):187-207. doi: 10.1016/0093-934x(84)90046-4.
Studies of aphasic patients using [18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia.
使用[18F]氟脱氧葡萄糖正电子计算机断层扫描对失语症患者进行的研究表明，左半球代谢抑制区域大于CT上显示的梗死区域。为了评估这些代谢差异与语言异常之间的关系，对11名患者进行了代谢扫描、CT检查，并对他们进行了波士顿失语症诊断量表和交际能力Porch指数测试。对代谢、CT和语言数据进行了相关性分析。CT显示，说话、口头阅读和复述与韦尼克区有可靠的相关性，这与当前的解剖学语言模型一致，而来自传统韦尼克区后方、下方和上方区域以及尾状核头部的代谢数据也与失语症语言功能有可靠的相关性。同时利用大脑结构和代谢测量方法可能会增进我们对与失语症相关的语言解剖学的理解。
