小鼠IgG2aa和IgG2ab等位基因的核酸序列之间存在多种差异。
Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.
作者信息
Schreier P H, Bothwell A L, Mueller-Hill B, Baltimore D
出版信息
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4495-9. doi: 10.1073/pnas.78.7.4495.
Abstract
To compare the structure of IgG2a alleles we have determined the complete DNA sequence of the constant region, coding sequence, and 3' untranslated region of a cDNA clone, pAB gamma 2a-1, which was derived from the C57BL/6 mouse strain (b allotype). This sequence was compared with the corresponding IgG2a DNA sequence of BALB/c origin (a allotype). The DNA sequences showed 10% differences, and the deduced protein sequences differed by about 15%. These differences were not evenly distributed: most differences were in the hinge region, the CH3 domain and the 3' untranslated region. It is evident that many alterations in the IgG2a alleles have occurred since the a and b haplotypes were separated--some of these changes were point mutations but some appear to have resulted from gene conversion of the IgG2ab allele by the IgG2bb allele.
摘要
为了比较IgG2a等位基因的结构，我们测定了一个cDNA克隆pABγ2a - 1恒定区、编码序列和3'非翻译区的完整DNA序列，该克隆源自C57BL/6小鼠品系（b同种异型）。将此序列与源自BALB/c（a同种异型）的相应IgG2a DNA序列进行比较。DNA序列显示出10%的差异，推导的蛋白质序列差异约为15%。这些差异分布不均：大多数差异存在于铰链区、CH3结构域和3'非翻译区。显然，自a和b单倍型分离以来，IgG2a等位基因发生了许多改变——其中一些变化是点突变，但有些似乎是由IgG2bb等位基因对IgG2ab等位基因的基因转换导致的。
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本文引用的文献
1
Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.兔血清蛋白的同种异型。I. 免疫化学分析确定七种主要同种异型的个体差异
J Exp Med. 1960 Jul 1;112(1):107-24. doi: 10.1084/jem.112.1.107.
2
Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.人类胎儿Gγ-和Aγ-珠蛋白基因：完整的核苷酸序列表明，这些重复基因之间可发生DNA交换。
Cell. 1980 Oct;21(3):627-38. doi: 10.1016/0092-8674(80)90426-2.
3
Intergenic conversion and reiterated genes.基因间转换与重复基因
Nature. 1981 Mar 19;290(5803):191-2. doi: 10.1038/290191a0.
4
Primary structural: analysis of the transplantation antigens of the murine H-2 major histocompatibility complex.主要结构：小鼠H-2主要组织相容性复合体移植抗原的分析
Annu Rev Biochem. 1981;50:1025-52. doi: 10.1146/annurev.bi.50.070181.005113.
5
Gene conversion: some implications for immunoglobulin genes.基因转换：对免疫球蛋白基因的一些影响。
Cell. 1981 Jun;24(3):592-4. doi: 10.1016/0092-8674(81)90082-9.
6
The structure and evolution of the human beta-globin gene family.人类β-珠蛋白基因家族的结构与进化
Cell. 1980 Oct;21(3):653-68. doi: 10.1016/0092-8674(80)90429-8.
7
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