小鼠Balb/cγ2a重链信使核糖核酸的恒定区和3'非翻译区的结构
Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.
作者信息
Sikorav J L, Auffray C, Rougeon F
出版信息
Nucleic Acids Res. 1980 Jul 25;8(14):3143-55. doi: 10.1093/nar/8.14.3143.
Abstract
The complete sequence for the constant and 3' untranslated regions of a mouse gamma 2a immunoglobulin heavy chain mRNA is reported. The sequence is 1093 nucleotides long coding for the CH1 (amino-acids 118-214), the Hinge (215-230), the CH2 (231-340) and the CH3 (341-447). The 3' untranslated region is 103 nucleotides long preceding the poly(A). The nucleotide sequence predicts as in the case for gamma 1 and gamma 2b heavy chains an additional lysine residue before the termination codon. This sequence has been compared to the corresponding sequences of gamma 1 and gamma 2b heavy chain mRNAs. These sequences are respectively 75% and 84% homologous. The CH2 domains of gamma 2a and gamma 2b are 95% homologous at the nucleotide level. The cross-over point of a gamma 2a - gamma 2b heavy chain variant is located in a segment of 73 perfectly matching nucleotides. The 3' non coding regions of gamma 2a and gamma 2b are 89% homologous.
摘要
报道了小鼠γ2a免疫球蛋白重链mRNA恒定区和3'非翻译区的完整序列。该序列长1093个核苷酸，编码CH1（氨基酸118 - 214）、铰链区（215 - 230）、CH2（231 - 340）和CH3（341 - 447）。3'非翻译区在poly(A)之前长103个核苷酸。核苷酸序列预测，与γ1和γ2b重链情况一样，在终止密码子之前有一个额外的赖氨酸残基。该序列已与γ1和γ2b重链mRNA的相应序列进行比较。这些序列的同源性分别为75%和84%。γ2a和γ2b的CH2结构域在核苷酸水平上同源性为95%。γ2a - γ2b重链变体的交叉点位于一段73个完全匹配核苷酸的片段中。γ2a和γ2b的3'非编码区同源性为89%。
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