Thrall R S, Phan S H, McCormick J R, Ward P A
Am J Pathol. 1981 Oct;105(1):76-81.
The development of bleomycin-induced pulmonary fibrosis was studied in rats depleted of neutrophils for 1 week and in rats depleted of complement for 1 week. Lung injury was assessed by histologic evaluation and by the biochemical measurement of total lung collagen. Qualitatively, histologic evidence of damage induced by bleomycin showed that damage progressed in a similar manner in neutropenic and complement-depleted animals when compared with normal animals. However, analysis of total lung collagen at 1 week after bleomycin administration revealed that collagen deposition was increased in neutropenic animals and decreased in animals depleted of complement when compared with untreated animals that received bleomycin. There were no significant differences in lung collagen levels at 1 month after bleomycin treatment in neutrophil-depleted or complement-depleted animals when compared with animals that received bleomycin alone.
研究了中性粒细胞耗竭1周的大鼠和补体耗竭1周的大鼠中博来霉素诱导的肺纤维化的发展情况。通过组织学评估和全肺胶原蛋白的生化测定来评估肺损伤。定性地说，博来霉素诱导的损伤的组织学证据表明，与正常动物相比，中性粒细胞减少和补体耗竭的动物中损伤以相似的方式进展。然而，博来霉素给药1周后全肺胶原蛋白的分析显示，与接受博来霉素的未治疗动物相比，中性粒细胞减少的动物中胶原蛋白沉积增加，而补体耗竭的动物中胶原蛋白沉积减少。与单独接受博来霉素的动物相比，博来霉素治疗1个月后，中性粒细胞减少或补体耗竭的动物的肺胶原蛋白水平没有显著差异。
