一种携带免疫球蛋白、Ia和Lyt-1决定簇的独特型特异性辅助细胞群体。
An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants.
作者信息
Sherr D H, Dorf M E
出版信息
J Exp Med. 1984 Apr 1;159(4):1189-200. doi: 10.1084/jem.159.4.1189.
Abstract
A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surface phenotype is Lyt-1.2+, Ig+, Lyb-3+, Thy-1.2-, Lyt-2.2-. The helper activity of the BH population is IgH restricted and BH cells selectively bind NPb idiotypic determinants. Collectively the data demonstrate that this unique subpopulation can regulate the response of antibody-secreting B cells through specific recognition of idiotypic determinants.
摘要
本文描述了一种具有B细胞和T细胞表型特征的辅助细胞群体。这种辅助性细胞群体称为BH，存在于正常未致敏的C57BL/6小鼠中，在没有T辅助细胞的情况下，优先促进表达携带NPb独特型的抗体形成B细胞的表达。其表面表型为Lyt-1.2+、Ig+、Lyb-3+、Thy-1.2-、Lyt-2.2-。BH群体的辅助活性受IgH限制，且BH细胞选择性结合NPb独特型决定簇。总体而言，这些数据表明，这一独特的亚群可通过对独特型决定簇的特异性识别来调节抗体分泌B细胞的反应。
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本文引用的文献
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