T细胞杂交瘤的分析。I. H-2和免疫球蛋白重链基因座限制的单克隆抑制因子的特性
Analysis of T cell hybridomas. I. Characterization of H-2 and Igh-restricted monoclonal suppressor factors.
作者信息
Minami M, Okuda K, Furusawa S, Benacerraf B, Dorf M E
出版信息
J Exp Med. 1981 Nov 1;154(5):1390-402. doi: 10.1084/jem.154.5.1390.
Abstract
Five hybridoma T cell lines were prepared by fusion of second order suppressor T cells (Ts2) with the BW5147 thymoma. The culture supernates from these T cell hybrids contained a factor, TsF2, which specifically suppressed 4-hydroxy-3-nitrophenyl acetyl hapten (NP)-induced cutaneous sensitivity responses. TsF2 activity was observed when the factor was administered during the effector phases of the immune response. TsF2 bears I-J determinants and has binding specificity for NPb idiotypic determinants. TsF2 suppressor activity could be absorbed on antigen-primed H-2-incompatible T cells but cannot suppress H-2-incompatible mice. In addition to this H-2 restriction, which maps to the I-J subregion, monoclonal TsF2 also has an Igh genetic restriction. The present results are combined with previous data to describe the cellular interactions leading to immune suppression.
摘要
通过将二级抑制性T细胞（Ts2）与BW5147胸腺瘤细胞融合，制备了5种杂交瘤T细胞系。这些T细胞杂交瘤的培养上清液中含有一种因子，即TsF2，它能特异性抑制4-羟基-3-硝基苯基乙酰半抗原（NP）诱导的皮肤敏感性反应。当在免疫反应的效应阶段给予该因子时，可观察到TsF2的活性。TsF2带有I-J决定簇，并且对NPb独特型决定簇具有结合特异性。TsF2抑制活性可被抗原致敏的H-2不相容T细胞吸收，但不能抑制H-2不相容小鼠。除了这种定位于I-J亚区的H-2限制外，单克隆TsF2还具有Igh基因限制。将目前的结果与先前的数据相结合，以描述导致免疫抑制的细胞间相互作用。
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