抗生素和抗病毒药物不会改变小鼠实验性诱导的克雅氏病。
Antibiotics and antivirals do not modify experimentally-induced Creutzfeldt-Jakob disease in mice.
作者信息
Tateishi J
出版信息
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):723-4. doi: 10.1136/jnnp.44.8.723.
Abstract
Thiamphenicol, rifampicin, amantadine, cytosine arabinoside and isoprinosine were administered to mice which were inoculated with brain tissue containing Creutzfeldt-Jakob disease (CJD). All the mice developed disease within 3 to 6 months after inoculation. As there was no significant shift in incubation periods among animal groups of each drug administration and non-administration, these compounds had no effect in controlling experimental CJD.
摘要
将甲砜霉素、利福平、金刚烷胺、阿糖胞苷和异丙肌苷给予接种含有克雅氏病（CJD）脑组织的小鼠。所有小鼠在接种后3至6个月内发病。由于给药组和未给药组动物之间的潜伏期没有显著变化，这些化合物对控制实验性CJD无效。
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