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人类亚急性海绵状脑病向小型啮齿动物的实验性传播。III. 来自三名患者的进一步传播及小鼠病变的分布模式

Experimental transmission of human subacute spongiform encephalopathy to small rodents. III. Further transmission from three patients and distribution patterns of lesions in mice.

作者信息

Tateishi J, Doi H, Sato Y, Suetsugu M, Ishii K, Kuroiwa Y

出版信息

Acta Neuropathol. 1981;53(2):161-3. doi: 10.1007/BF00689997.

DOI:10.1007/BF00689997
PMID:7010877
Abstract

Further experimental transmission of Creutzfeldt-Jakob disease (CJD) from three patients to mice and rats was carried out successfully. The clinical signs and pathologic features of spongiform encephalopathy transmitted to animals were much the same as in previous experiments, except that distribution of the lesions in the mice differed with each inoculated material taken from the patients. These observations suggest that multiplicity of CJD agents, as in the case of scrapie agents.

摘要

克雅氏病（CJD）从三名患者成功地进一步实验性传播给小鼠和大鼠。传播给动物的海绵状脑病的临床症状和病理特征与先前实验中的情况大致相同，只是从小鼠身上接种的每种取自患者的材料，其在小鼠体内的病变分布有所不同。这些观察结果表明，与羊瘙痒病病原体的情况一样，克雅氏病病原体具有多样性。

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Experimental transmission of human subacute spongiform encephalopathy to small rodents. III. Further transmission from three patients and distribution patterns of lesions in mice.人类亚急性海绵状脑病向小型啮齿动物的实验性传播。III. 来自三名患者的进一步传播及小鼠病变的分布模式
Acta Neuropathol. 1981;53(2):161-3. doi: 10.1007/BF00689997.
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Bovine spongiform encephalopathy in cattle mimics ultrastructurally experimental scrapie and Creutzfeldt-Jakob disease in rodents.牛的牛海绵状脑病在超微结构上类似于啮齿动物的实验性羊瘙痒病和克雅氏病。
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Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents.伴有库鲁氏斑的慢性海绵状脑病从人类向小型啮齿动物的传播。
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Transmission of Alpers' disease (chronic progressive encephalopathy) produces experimental Creutzfeldt-Jakob disease in hamsters.阿尔珀斯病（慢性进行性脑病）的传播可在仓鼠中引发实验性克雅氏病。
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Experimental transmission of human subacute spongiform encephalopathy to small rodents. IV. Positive transmission from a typical case of Gerstmann-Sträussler-Scheinker's disease.人类亚急性海绵状脑病向小型啮齿动物的实验性传播。IV. 来自典型格斯特曼-施特劳斯勒-谢inker病病例的阳性传播。
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Spongiform encephalopathy transmitted experimentally from Creutzfeldt-Jakob and familial Gerstmann-Sträussler-Scheinker diseases.实验性传播自克雅氏病和家族性格斯特曼-施特劳斯勒-谢克尔病的海绵状脑病。
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Virus-induced subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). A report of two Chinese cases with clinico-pathologic studies.病毒诱导的亚急性海绵状脑病（克雅氏病）。两例中国病例的临床病理研究报告。
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Proposed link between transmissible spongiform encephalopathies of man and animals.人类与动物可传播性海绵状脑病之间的潜在联系。
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引用本文的文献

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The Evolution of Experimental Rodent Models for Prion Diseases.朊病毒疾病实验啮齿动物模型的演变
J Neurochem. 2025 Mar;169(3):e70039. doi: 10.1111/jnc.70039.
2
Early MRI findings in Creutzfeldt-Jakob disease.克雅氏病的早期磁共振成像表现
J Neurol. 1993 Jul;240(7):423-6. doi: 10.1007/BF00867355.
3
Accumulation of abnormal prion protein in mice infected with Creutzfeldt-Jakob disease via intraperitoneal route: a sequential study.经腹腔途径感染克雅氏病的小鼠体内异常朊病毒蛋白的积累：一项序贯研究。

本文引用的文献

1
Experimental transmission of human subacute spongiform encephalopathy to small rodents. I. Clinical and histological observations.人类亚急性海绵状脑病向小型啮齿动物的实验性传播。I. 临床和组织学观察
Acta Neuropathol. 1980;51(2):127-34. doi: 10.1007/BF00690454.
2
Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation.小鼠的羊瘙痒病。灰质空泡化分布和强度的病原体株差异。
J Comp Pathol. 1973 Jan;83(1):29-40. doi: 10.1016/0021-9975(73)90024-8.
Am J Pathol. 1993 Nov;143(5):1470-9.
4
Species barrier prevents an abnormal isoform of prion protein from accumulating in follicular dendritic cells of mice with Creutzfeldt-Jakob disease.物种屏障可防止朊病毒蛋白的异常异构体在克雅氏病小鼠的滤泡树突状细胞中积累。
J Virol. 1993 Nov;67(11):6808-10. doi: 10.1128/JVI.67.11.6808-6810.1993.
5
Evidence for an unconventional virus in mouse-adapted Creutzfeldt-Jakob disease.小鼠适应性克雅氏病中存在非常规病毒的证据。
Infect Immun. 1982 Sep;37(3):1050-3. doi: 10.1128/iai.37.3.1050-1053.1982.
6
Antibiotics and antivirals do not modify experimentally-induced Creutzfeldt-Jakob disease in mice.抗生素和抗病毒药物不会改变小鼠实验性诱导的克雅氏病。
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):723-4. doi: 10.1136/jnnp.44.8.723.
7
Immunohistochemical confirmation of Creutzfeldt-Jakob disease with a long clinical course with amyloid plaque core antibodies.用淀粉样斑块核心抗体对临床病程较长的克雅氏病进行免疫组织化学确诊。
Am J Pathol. 1988 Jun;131(3):435-43.
8
Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease.在患有克雅氏病的小鼠中，异常形式的朊病毒蛋白在滤泡树突状细胞中积累。
J Virol. 1991 Nov;65(11):6292-5. doi: 10.1128/JVI.65.11.6292-6295.1991.
9
The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease.克雅氏病小鼠体内异常朊病毒蛋白积累的顺序性发展。
Am J Pathol. 1992 Jun;140(6):1411-20.