对食物蛋白过敏的大鼠中，特异性抗原排斥和非特异性促进抗原穿过肠道的作用。
Specific antigen exclusion and non-specific facilitation of antigen entry across the gut in rats allergic to food proteins.
作者信息
Roberts S A, Reinhardt M C, Paganelli R, Levinsky R J
出版信息
Clin Exp Immunol. 1981 Jul;45(1):131-6.
Abstract
The intestinal absorption of ovalbumin and beta-lactoglobulin was measured in Hooded Lister rats which had previously been made allergic to ovalbumin, and in unimmunized controls. The antigens were introduced both together and separately into closed intestinal loops. Absorption of free ovalbumin, but not beta-lactoglobulin, was reduced in rats with anti-ovalbumin antibody, demonstrating antigen-specific immune exclusion despite the presence of reaginic antibody. In contrast, the absorption of beta-lactoglobulin was enhanced by the presence of ovalbumin in rats with IgE anti-ovalbumin, but not in unimmunized controls. These results suggest that macromolecular absorption may be increased in an antigen non-specific way in food allergy.
摘要
在先前已对卵清蛋白过敏的帽状利斯特大鼠以及未免疫的对照大鼠中，测量了卵清蛋白和β-乳球蛋白的肠道吸收情况。将抗原一起和分别引入封闭的肠袢中。在具有抗卵清蛋白抗体的大鼠中，游离卵清蛋白的吸收减少，但β-乳球蛋白的吸收未减少，这表明尽管存在反应素抗体，但仍存在抗原特异性免疫排斥。相比之下，在具有IgE抗卵清蛋白的大鼠中，卵清蛋白的存在会增强β-乳球蛋白的吸收，但在未免疫的对照大鼠中则不会。这些结果表明，在食物过敏中，大分子吸收可能以抗原非特异性方式增加。
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