Agren H
Psychiatry Res. 1980 Oct;3(2):225-36. doi: 10.1016/0165-1781(80)90039-6.
Suicidality scores from the Schedule for Affective Disorders and Schizophrenia on 21 unipolar and 12 bipolar depressives were correlated with monoamine metabolites in the cerebrospinal fluid using multiple regression analyses. The single item of Suicidal Tendencies Worst Week correlated highly significantly and negatively with 3-methoxy-4-hydroxyphenylglycol (MHPG) and only to a very slight degree with 5-hydroxyindoleacetic acid (5HIAA). Seriousness of Intent of Worst Suicide Attempt earlier in life correlated significantly and negatively with both MHPG and 5HIAA. Subjective Anger was positively and Overt Anger negatively associated with thoughts of suicide. The results support earlier reports that depressives with low 5HIAA are prone to violent suicides, but also point to the equal, if not even greater involvement of MHPG and noradrenergic neuronal systems in carrying out a wish for death.
使用多元回归分析，对21名单相抑郁症患者和12名双相抑郁症患者的情感障碍和精神分裂症量表中的自杀倾向得分与脑脊液中的单胺代谢产物进行相关性分析。“自杀倾向最严重周”这一单项与3-甲氧基-4-羟基苯乙二醇（MHPG）高度显著负相关，与5-羟吲哚乙酸（5HIAA）仅呈非常轻微的负相关。早年最严重自杀未遂的意图严重程度与MHPG和5HIAA均显著负相关。主观愤怒与自杀念头呈正相关，公开愤怒与自杀念头呈负相关。研究结果支持了早期的报告，即5HIAA水平低的抑郁症患者容易发生暴力自杀行为，但也指出，即使MHPG和去甲肾上腺素能神经元系统在实现死亡愿望中的参与程度不更高，至少也是同等重要的。
