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抑郁症患者自杀的遗传和生物学危险因素。

Genetic and biologic risk factors for suicide in depressive disorders.

作者信息

Roy A

出版信息

Psychiatr Q. 1993 Winter;64(4):345-58. doi: 10.1007/BF01064927.

DOI:10.1007/BF01064927
PMID:8234546
Abstract

Over the last few years data have accumulated suggesting that there may be genetic and biologic risk factors for suicide. This paper reviews studies from clinical populations, twins, the Amish, as well as data from the Iowa-500 and Danish-American adoption studies which suggest that there may be a genetic factor predisposing to suicide. The paper also reviews neurochemical data from cerebrospinal fluid, urine and postmortem studies which suggest that diminished central serotonin and dopamine may be implicated in suicidal behavior.

摘要

在过去几年中,积累的数据表明,可能存在自杀的遗传和生物学风险因素。本文回顾了来自临床人群、双胞胎、阿米什人以及爱荷华500研究和丹麦-美国收养研究的数据,这些研究表明可能存在一种导致自杀的遗传因素。本文还回顾了来自脑脊液、尿液和尸检研究的神经化学数据,这些数据表明中枢5-羟色胺和多巴胺水平降低可能与自杀行为有关。

相似文献

1
Genetic and biologic risk factors for suicide in depressive disorders.抑郁症患者自杀的遗传和生物学危险因素。
Psychiatr Q. 1993 Winter;64(4):345-58. doi: 10.1007/BF01064927.
2
Genetics of suicide in depression.抑郁症中自杀行为的遗传学
J Clin Psychiatry. 1999;60 Suppl 2:12-7; discussion 18-20, 113-6.
3
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use.大麻依赖和早发性大麻使用不一致的双胞胎中的重度抑郁症、自杀意念和自杀未遂。
Arch Gen Psychiatry. 2004 Oct;61(10):1026-32. doi: 10.1001/archpsyc.61.10.1026.
4
Recent biologic studies on suicide.近期关于自杀的生物学研究。
Suicide Life Threat Behav. 1994 Spring;24(1):10-4.
5
[Biological aspects of suicide].[自杀的生物学方面]
Acta Psychiatr Belg. 1983 Jan-Feb;83(1):7-12.
6
Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study.抑郁症患者脑脊液单胺代谢产物与自杀行为。一项5年随访研究。
Arch Gen Psychiatry. 1989 Jul;46(7):609-12. doi: 10.1001/archpsyc.1989.01810070035005.
7
Genetics of suicide.自杀的遗传学
Ann N Y Acad Sci. 1986;487:97-105. doi: 10.1111/j.1749-6632.1986.tb27889.x.
8
Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide.有自杀企图的抑郁症患者多巴胺代谢指标显著降低。
Arch Gen Psychiatry. 1992 Jun;49(6):447-50. doi: 10.1001/archpsyc.1992.01820060027004.
9
Sexual orientation and suicidality: a co-twin control study in adult men.性取向与自杀倾向:成年男性的双胞胎对照研究
Arch Gen Psychiatry. 1999 Oct;56(10):867-74. doi: 10.1001/archpsyc.56.10.867.
10
[Analysis of suicidal tendencies in twins].[双胞胎自杀倾向分析]
Orv Hetil. 1984 Apr 8;125(15):918-9.

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Depressive Symptoms and Suicidal Ideation Among Symptomatic Patients With a History of Lyme Disease vs Two Comparison Groups.有莱姆病病史的症状性患者中抑郁症状和自杀意念与两个对照组比较。
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Association of Migraine Headaches With Suicidal Ideation Among Pregnant Women in Lima, Peru.

本文引用的文献

1
AFFECTIVE DISORDER. 3. DIAGNOSTIC CORRELATES AND INCIDENCE OF SUICIDE.情感障碍。3. 自杀的诊断关联因素及发生率。
J Nerv Ment Dis. 1964 Aug;139:176-81.
2
A suicidal family.一个自杀倾向的家庭。
Br J Psychiatry. 1981 Jul;139:68-9. doi: 10.1192/bjp.139.1.68.
3
Risk factors for suicide in psychiatric patients.精神科患者自杀的危险因素。
秘鲁利马孕妇偏头痛与自杀意念的关联。
Headache. 2016 Apr;56(4):741-9. doi: 10.1111/head.12793. Epub 2016 Mar 26.
4
Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder.可能与重性抑郁症自杀行为相关的 5-羟色胺转运体基因多态性。
Psychiatry Investig. 2015 Jan;12(1):136-41. doi: 10.4306/pi.2015.12.1.136. Epub 2015 Jan 12.
5
Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters.自杀尸检研究中差异表达基因对健康受试者和自杀未遂者作为内表型的人格特质的影响。
Eur Arch Psychiatry Clin Neurosci. 2014 Aug;264(5):423-32. doi: 10.1007/s00406-013-0469-1. Epub 2013 Nov 16.
6
Endophenotypes as a measure of suicidality.内表型作为自杀倾向的衡量标准。
J Appl Genet. 2012 Nov;53(4):389-413. doi: 10.1007/s13353-012-0113-1. Epub 2012 Sep 2.
7
Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.神经营养因子受体编码基因NTRK2中的基因变异与抑郁症患者自杀未遂的终生病史之间的关联。
Arch Gen Psychiatry. 2010 Apr;67(4):348-59. doi: 10.1001/archgenpsychiatry.2009.201. Epub 2010 Feb 1.
8
Suicidality in pediatric bipolar disorder.儿童双相情感障碍中的自杀倾向
Child Adolesc Psychiatr Clin N Am. 2009 Apr;18(2):339-52, viii. doi: 10.1016/j.chc.2008.11.005.
9
Posttraumatic stress disorder and suicide attempts in a community sample of urban american young adults.美国城市青年成年人社区样本中的创伤后应激障碍与自杀未遂
Arch Gen Psychiatry. 2009 Mar;66(3):305-11. doi: 10.1001/archgenpsychiatry.2008.557.
10
Adolescent depression, family psychopathology and parent/child relations: a case control study.青少年抑郁症、家庭精神病理学与亲子关系:一项病例对照研究。
Can Child Adolesc Psychiatr Rev. 2003 Feb;12(1):2-9.
Arch Gen Psychiatry. 1982 Sep;39(9):1089-95. doi: 10.1001/archpsyc.1982.04290090071014.
4
Risk of suicide in the relatives of schizophrenics, manics, depressives, and controls.
J Clin Psychiatry. 1983 Nov;44(11):396-7, 398-400.
5
Family history of suicide.
Arch Gen Psychiatry. 1983 Sep;40(9):971-4. doi: 10.1001/archpsyc.1983.01790080053007.
6
Biochemical markers in suicidal patients. Investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests.自杀患者的生化标志物。脑脊液胺代谢产物及神经内分泌检测研究。
J Affect Disord. 1984 Jun;6(3-4):341-50. doi: 10.1016/s0165-0327(84)80012-9.
7
Depression, suicide and the metabolism of serotonin in the brain.抑郁症、自杀与大脑中的血清素代谢
J Affect Disord. 1982 Dec;4(4):275-90. doi: 10.1016/0165-0327(82)90025-8.
8
Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid: II. Suicide.单相和双相抑郁症的症状模式与脑脊液中单胺代谢产物的相关性:II. 自杀
Psychiatry Res. 1980 Oct;3(2):225-36. doi: 10.1016/0165-1781(80)90039-6.
9
Monoamine metabolites in CSF and suicidal behavior.脑脊液中的单胺代谢物与自杀行为。
Arch Gen Psychiatry. 1981 Jun;38(6):631-6. doi: 10.1001/archpsyc.1981.01780310031002.
10
Pharmacological prevention of suicidal behaviour.
J Affect Disord. 1982 Dec;4(4):291-8. doi: 10.1016/0165-0327(82)90026-x.