The interrelations of some humoral factors of resistance with the prevalence of respiratory diseases in children. II. Interactions of humoral factors.

In a previous study the levels of nine serum and two salivary proteins were measured in a group of 80 children. Some significant differences of mean levels were found between the group of children, who remained well and who fell ill in the school year following the examination. In the present study the discrimination analysis was performed between both mentioned ill and healthy subgroups of children, referring to possible interaction of two protein tested. The comparison showed significant difference between double-protein combinations in 17 from 36 possibilities in girls subgroup. Relevant double combinations were assessed only in five of nine tested proteins: IgE, IgA, CPL, TRF and A 1-AT. Two combinations revealed the greatest significance: IgE with IgA, and IgE with CPL. No such significance was found in boys subgroup. The results suggest that prevalence of respiratory disease in influenced not only by previous levels of some single proteins, how it was found in the first paper, but also by the interactions of certain proteins.