Gottlieb K
Hum Genet. 1981;58(4):429-31. doi: 10.1007/BF00282830.
The present study is the first to investigate gametic disequilibrium of loosely linked loci (recombination greater than 22%) of known map distance in humans. The study population consisted of 302 healthy unrelated individuals of whit mixed-European ancestry living in the Denver, Colorado area. Pair-wise combinations of four loci on chromosome 1 (Rhesus, Duffy, phosphoglucomutase-1, and amylase-2) were examined for nonrandom association of alleles at different loci. Observed and expected values were compared with chi-square goodness-of-fit tests. There was no evidence of first-order interaction, i.e., gametic disequilibrium. From these findings it seems that gametic disequilibrium may not be important in the genetic organization of chromosome 1.
本研究首次对人类已知图谱距离的松散连锁基因座（重组率大于22%）的配子不平衡进行了调查。研究人群包括302名生活在科罗拉多州丹佛市的、具有欧洲混合血统的健康无关个体。对1号染色体上四个基因座（恒河猴血型、达菲血型、磷酸葡萄糖变位酶-1和淀粉酶-2）的成对组合进行了检查，以确定不同基因座上等位基因的非随机关联。通过卡方拟合优度检验比较观察值和期望值。没有证据表明存在一级相互作用，即配子不平衡。从这些发现来看，配子不平衡在1号染色体的遗传组织中可能并不重要。
