Gametic equilibrium of four loci on chromosome 1.

The present study is the first to investigate gametic disequilibrium of loosely linked loci (recombination greater than 22%) of known map distance in humans. The study population consisted of 302 healthy unrelated individuals of whit mixed-European ancestry living in the Denver, Colorado area. Pair-wise combinations of four loci on chromosome 1 (Rhesus, Duffy, phosphoglucomutase-1, and amylase-2) were examined for nonrandom association of alleles at different loci. Observed and expected values were compared with chi-square goodness-of-fit tests. There was no evidence of first-order interaction, i.e., gametic disequilibrium. From these findings it seems that gametic disequilibrium may not be important in the genetic organization of chromosome 1.