Zemskov A M, Suleĭmanov S M
Zh Mikrobiol Epidemiol Immunobiol. 1981 Dec(12):88-93.
Type A Cl. perfringens toxin caused necrosis in guniea-pigs and killed mice. Sodium nucleinate, administered orally to these animals simultaneously with the injection of the toxin and 2 hours later significantly prevented dermonecrosis in guinea-pigs and death in mice, as well as the development of pathomorphological changes in the liver, the kidneys and the spleen, the fatty degeneration of hepatocytes and disturbances in nucleic acid metabolism in these cells.
A型产气荚膜梭菌毒素可导致豚鼠坏死并使小鼠死亡。将核酸钠与毒素注射同时经口给予这些动物，并在2小时后显著预防了豚鼠的皮肤坏死和小鼠的死亡，以及肝脏、肾脏和脾脏病理形态学变化的发展、肝细胞的脂肪变性和这些细胞中核酸代谢的紊乱。
