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相似文献

1
Multiple biological activities of homogeneous human alpha interferon.人α干扰素同质性的多种生物学活性
Infect Immun. 1981 Dec;34(3):1068-70. doi: 10.1128/iai.34.3.1068-1070.1981.
2
In vitro interactions of purified cloned human interferons on NK cells: enhanced activation.
J Immunol. 1982 Sep;129(3):934-5.
3
Enhancement of mouse NK cells by interferon.干扰素对小鼠自然杀伤细胞的增强作用。
Transplant Proc. 1979 Mar;11(1):993-6.
4
Metabolic requirements for the in vitro augmentation of mouse natural killer activity by interferon.干扰素体外增强小鼠自然杀伤活性的代谢需求
Cell Immunol. 1981 Feb;58(1):49-60. doi: 10.1016/0008-8749(81)90148-9.
5
Induction and kinetics of natural killer cells in humans following interferon therapy.干扰素治疗后人体自然杀伤细胞的诱导及动力学
Nature. 1979 Nov 22;282(5737):417-9. doi: 10.1038/282417a0.
6
Regulation of susceptibility to natural killer cells' cytotoxicity and regulation of HLA synthesis: differing efficacies of alpha, beta, and gamma interferons.
J Interferon Res. 1982;2(3):329-38. doi: 10.1089/jir.1982.2.329.
7
[Natural killer cells in the interferon therapy of cancer patients].[癌症患者干扰素治疗中的自然杀伤细胞]
Vopr Onkol. 1991;37(2):136-43.
8
Effects of ouabain on the anticellular and antiviral activities of human and mouse interferon.哇巴因对人及小鼠干扰素的抗细胞和抗病毒活性的影响。
J Gen Virol. 1977 Mar;34(3):537-40. doi: 10.1099/0022-1317-34-3-537.
9
Medullasin enhances human natural killer cell activity by a mechanism other than the induction of interferons or interleukin-2.
Jpn J Cancer Res. 1987 Jan;78(1):68-73.
10
Human natural killer cells.人类自然杀伤细胞。
Transplant Proc. 1979 Mar;11(1):807-10.

本文引用的文献

1
Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.体外刺激的人巨噬细胞样细胞系的表征：巨噬细胞功能模型
J Immunol. 1980 Jul;125(1):6-12.
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Mouse interferons: amino terminal amino acid sequences of various species.小鼠干扰素：不同物种的氨基末端氨基酸序列。
Science. 1980 Feb 1;207(4430):528-30. doi: 10.1126/science.7352261.
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Amino terminal sequence of the major component of human lymphoblastoid interferon.人淋巴母细胞样干扰素主要成分的氨基末端序列。
Science. 1980 Feb 1;207(4430):527-8. doi: 10.1126/science.7352260.
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New protein sequenator with increased sensitivity.灵敏度更高的新型蛋白质测序仪。
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Proliferative and functional aspects of interferon-treated human normal and neoplastic T and B cells.干扰素处理的人类正常及肿瘤性T细胞和B细胞的增殖与功能方面
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7
Human leukocyte and fibroblast interferons are structurally related.人白细胞干扰素和成纤维细胞干扰素在结构上相关。
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8
Partial purification of human interferon by affinity chromatography.通过亲和层析法对人干扰素进行部分纯化。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3139-42. doi: 10.1073/pnas.71.8.3139.
9
Affinity chromatography of human leukocyte and diploid cell interferons on sepharose-bound antibodies.人白细胞干扰素和二倍体细胞干扰素在琼脂糖结合抗体上的亲和层析
J Immunol. 1975 Feb;114(2 Pt 1):640-4.
10
Interferon: purification and initial characterization from human diploid cells.干扰素：从人二倍体细胞中纯化及初步特性鉴定
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人α干扰素同质性的多种生物学活性

Multiple biological activities of homogeneous human alpha interferon.

作者信息

Attallah A M, Zoon K, Folks T, Huntington J, Yeatman T J

出版信息

Infect Immun. 1981 Dec;34(3):1068-70. doi: 10.1128/iai.34.3.1068-1070.1981.

DOI:10.1128/iai.34.3.1068-1070.1981
PMID:6174447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC350977/
Abstract

To identify the active molecule in human alpha interferon preparations, we performed several studies, using both partially purified interferon and homogeneous interferon. Our results indicated that there is little difference between the partially purified and the homogeneous interferon preparations in terms of antiviral activity, inhibition of deoxyribonucleic acid synthesis in human neoplastic cells, and enhancement of human natural killer cell activity.

摘要

为了鉴定人α干扰素制剂中的活性分子，我们使用部分纯化的干扰素和均一的干扰素进行了多项研究。我们的结果表明，部分纯化的干扰素制剂和均一的干扰素制剂在抗病毒活性、抑制人肿瘤细胞中的脱氧核糖核酸合成以及增强人自然杀伤细胞活性方面几乎没有差异。