Hammond C V, Hammond M D, Taylor W A
Int Arch Allergy Appl Immunol. 1982;67(3):284-6. doi: 10.1159/000233032.
Passively sensitized human lung, when incubated with the appropriate allergen, released histamine and slow-reacting substance (SRS-A). Betamethasone sodium phosphate (5-100 microgram/ml), preincubated with the lung overnight, suppressed, in a dose-related manner, the release of SRS-A without having an effect on the release of histamine. Preincubation for only 1 h produced little effect on the release of SRS-A or of histamine. These results may help to explain some of the beneficial effects of glucocorticoids in allergic asthma.
被动致敏的人肺组织在与适当的变应原一起孵育时，会释放组胺和慢反应物质（SRS-A）。倍他米松磷酸钠（5 - 100微克/毫升）与肺组织预先孵育过夜，以剂量相关的方式抑制SRS-A的释放，而对组胺的释放没有影响。仅预先孵育1小时对SRS-A或组胺的释放几乎没有影响。这些结果可能有助于解释糖皮质激素在过敏性哮喘中的一些有益作用。
