Miyazaki M, Watanabe A
Int J Cancer. 1982 Feb 15;29(2):213-6. doi: 10.1002/ijc.2910290217.
The levels of serum alpha-fetoprotein (AFP) in rats were determined during hepatocarcinogenesis with ethionine, and the effects of methionine administration on serum AFP elevation in these animals were studied with the aim of investigating regulatory mechanisms of AFP was observed 6 weeks following the start of feeding a diet containing 0.25% ethionine and again at the 22nd week of feeding, when a well-differentiated hepatoma had already developed. These biphasic elevations of serum AFP concentrations in rats fed a 0.25% ethionine-containing diet decreased abruptly an significantly following a change to the basal diet either supplemented with or without 0.7% methionine. The possibility that regulation of AFP production in these rats may correlate with methionine metabolisms is discussed on the basis of the experimental data obtained.
在使用乙硫氨酸诱导大鼠肝癌发生的过程中，测定了大鼠血清甲胎蛋白（AFP）的水平，并研究了给予蛋氨酸对这些动物血清AFP升高的影响，目的是探究AFP的调节机制。在开始喂食含0.25%乙硫氨酸的饲料6周后以及喂食第22周时（此时已形成高分化肝癌）观察到血清AFP水平变化。在更换为添加或不添加0.7%蛋氨酸的基础饲料后，喂食含0.25%乙硫氨酸饲料的大鼠血清AFP浓度的这两个阶段的升高均显著且突然下降。根据所获得的实验数据，讨论了这些大鼠中AFP产生的调节可能与蛋氨酸代谢相关的可能性。
