大鼠肝脏损伤时甲胎蛋白产生的调节机制
Regulatory mechanisms of alpha-fetoprotein production in injured rat liver.
作者信息
Watanabe A, Nagashima H
出版信息
Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):102-5.
The role of alpha-fetoprotein (AFP)-suppressing factor(s) in the increased production of AFP in liver injury was investigated with carbon tetrachloride and ethionine-treated rats. Elevated concentrations of serum AFP induced by these treatments decreased upon administration of prednisolone. However, injections of methionine and adenosine 5'-triphosphate (ATP), which significantly accelerated the rapid fall of serum AFP levels after birth, produced no such effects on increased AFP levels in hepatic injury. This ineffectiveness of methionine and ATP may suggests that their metabolisms are impaired in the injured liver.
利用四氯化碳和乙硫氨酸处理的大鼠，研究了甲胎蛋白（AFP）抑制因子在肝损伤中AFP产生增加过程中的作用。这些处理诱导的血清AFP浓度升高在给予泼尼松龙后降低。然而，注射甲硫氨酸和5'-三磷酸腺苷（ATP），这在出生后能显著加速血清AFP水平的快速下降，但对肝损伤中升高的AFP水平没有此类作用。甲硫氨酸和ATP的这种无效性可能表明它们在受损肝脏中的代谢受到了损害。
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