Pollock S, Lewis P D, Kendall B
J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1104-9. doi: 10.1136/jnnp.44.12.1104.
Whipple's disease confined to the nervous system occurred in a 36-year old woman who presented with grand mal seizures and dementia. There was no evidence of extracerebral involvement and the jejunal biopsy was negative before treatment. Multiple enhancing lesions on CT scan progressed despite therapy with minocycline and prednisone, but resolved on treatment with tetracycline. The dementia did not progress while she was on antibiotic therapy. Whipple's disease should be considered as a treatable cause of progressive dementia even in the absence of an abnormal jejunal biopsy.
一名36岁女性患上了局限于神经系统的惠普尔病，表现为癫痫大发作和痴呆。没有脑外受累的证据，治疗前空肠活检结果为阴性。尽管使用米诺环素和泼尼松进行治疗，但CT扫描上的多个强化病灶仍有进展，而使用四环素治疗后病灶消退。在她接受抗生素治疗期间，痴呆症状没有进展。即使空肠活检结果正常，惠普尔病也应被视为进行性痴呆的可治疗病因。
