Steinsapir J, Rojas A M, Tchernitchin A
Am J Physiol. 1982 Feb;242(2):E121-6. doi: 10.1152/ajpendo.1982.242.2.E121.
Uterine edema induced by 0.1 microgram/100 g body wt of estradiol further increases in the presence of theophylline. Theophylline alone or in the presence of 0.001, 0.01, 0.1, and 1 microgram/100 g body wt of estradiol increases uterine RNA and protein content 6 h after its administration, as compared with the same doses of estradiol alone. Both phenomena disappear in the ovariectomized immature rat, suggesting that theophylline potentiates the action of gonadotropins, increasing the synthesis of endogenous ovarian estrogens by the immature ovary. Theophylline decreases the number of eosinophils in the blood and concurrently decreases estrogen-induced uterine eosinophilia at doses of 0.01, 0.1, 1, 10, and 30 micrograms/100 g body wt of estradiol. Estrogen binding by uterine eosinophils in vitro increases in the presence of theophylline. This effect of theophylline could also explain the increase in vivo in estrogen-induced uterine edema.
由每100克体重0.1微克雌二醇诱导的子宫水肿，在茶碱存在的情况下会进一步加重。与单独使用相同剂量的雌二醇相比，单独使用茶碱或在每100克体重0.001、0.01、0.1和1微克雌二醇存在的情况下，给药6小时后子宫RNA和蛋白质含量会增加。这两种现象在去卵巢的未成熟大鼠中消失，表明茶碱增强了促性腺激素的作用，增加了未成熟卵巢内源性卵巢雌激素的合成。在每100克体重0.01、0.1、1、10和30微克雌二醇的剂量下，茶碱会减少血液中嗜酸性粒细胞的数量，同时减少雌激素诱导的子宫嗜酸性粒细胞增多。在茶碱存在的情况下，体外子宫嗜酸性粒细胞与雌激素的结合增加。茶碱的这种作用也可以解释雌激素诱导的子宫水肿在体内的增加。
