Steinsapir J, Rojas A M, Fernández A, Alburquerque M, León S, Bustón P, Pacheco R, Munizaga A, Habash L, Ojeda J M, Tchernitchin A
J Endocrinol. 1979 Dec;83(3):277-84. doi: 10.1677/joe.0.0830277.
Theophylline alone or in the presence of 0.001, 0.01, 0.1 or 1 microgram oestradiol-17 beta/100 g body wt increase uterine RNA and protein content 6 h after administration. Uterine oedema induced by physiological doses of oestradiol-17 beta was increased further in the presence of theophylline. Theophylline decreased the number of eosinophils in the blood and concurrently decreased oestrogen-induced uterine oesinophilia at doses of 0.01, 0.1, 1, 10 or 30 micrograms oestradiol-17 beta/100 g body wt. Oestrogen binding by uterine eosinophils in vitro increased in the presence of theophylline. This effect of theophylline could explain the increase of oestrogen-induced uterine oedema in vivo.
单独使用茶碱或在存在0.001、0.01、0.1或1微克17β-雌二醇/100克体重的情况下，给药6小时后可增加子宫RNA和蛋白质含量。在茶碱存在的情况下，生理剂量的17β-雌二醇诱导的子宫水肿会进一步加重。茶碱可降低血液中嗜酸性粒细胞的数量，同时在剂量为0.01、0.1、1、10或30微克17β-雌二醇/100克体重时，可降低雌激素诱导的子宫嗜酸性粒细胞增多。在茶碱存在的情况下，体外子宫嗜酸性粒细胞的雌激素结合增加。茶碱的这种作用可以解释体内雌激素诱导的子宫水肿增加的原因。
