Steinsapir J, Rojas A M, Bruzzone M E, White A, Alarcón O, Fuentes I, Fierro C, González O, Ampuero R, Fuentes M
J Endocrinol. 1985 Jun;105(3):397-403. doi: 10.1677/joe.0.1050397.
In the ovariectomized adult rat uterine oedema induced by 0.01 and 0.1 micrograms oestradiol-17 beta/100g body weight increased further in the presence of theophylline. Nuclear retention of oestrogen-receptor complexes also increased in response to theophylline both in vivo and in vitro. Theophylline decreased the number of eosinophils in the blood and concurrently decreased oestrogen-induced uterine eosinophilia at doses of 0.001, 0.01, 0.1, 1, 10 or 30 micrograms oestradiol/100 g body weight, through a mechanism independent of glucocorticoids. There was, therefore, no correlation between changes in the number of uterine eosinophils and changes in uterine wet weight induced by theophylline and oestrogen. It is suggested that the presence of oestrogen-receptor complexes in the nucleus for at least 4 h is a prerequisite for the induction of uterine oedema and growth in the presence of theophylline and oestradiol-17 beta.
在去卵巢的成年大鼠中，体重100g的大鼠注射0.01和0.1微克的17β-雌二醇会诱发子宫水肿，而在茶碱存在的情况下，这种水肿会进一步加重。在体内和体外，茶碱都会使雌激素受体复合物在细胞核内的保留增加。茶碱会降低血液中嗜酸性粒细胞的数量，同时在剂量为0.001、0.01、0.1、1、10或30微克/100g体重的雌二醇作用下，通过一种独立于糖皮质激素的机制降低雌激素诱导的子宫嗜酸性粒细胞增多。因此，茶碱和雌激素引起的子宫嗜酸性粒细胞数量变化与子宫湿重变化之间没有相关性。有人提出，在茶碱和17β-雌二醇存在的情况下，细胞核内雌激素受体复合物至少存在4小时是诱发子宫水肿和生长的先决条件。
