骨髓瘤患者外周血单个核细胞上的细胞结合免疫球蛋白。
Cell-bound immunoglobulin on peripheral blood mononuclear cells of patients with myeloma.
作者信息
King M A, Wells J V
出版信息
Clin Exp Immunol. 1981 Sep;45(3):552-6.
Abstract
Four patients who had myeloma were examined for monoclonal lymphocytes in the peripheral blood using anti-idiotype antibodies. All the patients had received treatment and two were in apparent complete remission. In no case was there any evidence of peripheral blood mononuclear cells (PBMC) with endogenous surface idiotypic determinants, even in patients with active disease. It was found, however, that substantial cytophilic IgG may remain bound to Fc receptors on PBMC even after extensive incubation and washing at 37 degrees C.
摘要
使用抗独特型抗体对外周血中的单克隆淋巴细胞进行检测的4例骨髓瘤患者。所有患者均接受过治疗，其中2例处于明显的完全缓解期。即使在患有活动性疾病的患者中，也没有任何证据表明外周血单个核细胞（PBMC）带有内源性表面独特型决定簇。然而，研究发现，即使在37℃下进行长时间孵育和洗涤后，大量亲细胞性IgG仍可能与PBMC上的Fc受体结合。
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