博来霉素处理后球体中细胞亚群的差异存活情况。
Differential survival of cell subpopulations in spheroids after treatment with bleomycin.
作者信息
Tobüren D
出版信息
J Cancer Res Clin Oncol. 1981;102(2):189-93. doi: 10.1007/BF00410671.
Abstract
The cytotoxic effect of bleomycin (BLM) on Chinese hamster V79-cells grown as spheroids is compared to that on monolayer cultures in exponential vs. plateau phase of growth. Cells treated as intact spheroids with BLM (50 micrograms/ml for 1 h) are more sensitive than monolayer cultures. Cell subpopulations derived from different zones of the spheroids survive BLM-treatment to different degrees: When treated as single cells in suspension, the formerly "outer" cells are less affected than the "inner" cells. Within intact spheroids, however, progressive cellular resistance with increasing distance from the outer rim is found.
摘要
将博来霉素（BLM）对呈球体生长的中国仓鼠V79细胞的细胞毒性作用与处于指数生长期和平稳期的单层培养细胞的细胞毒性作用进行比较。用BLM（50微克/毫升，处理1小时）处理完整球体形式的细胞比单层培养细胞更敏感。源自球体不同区域的细胞亚群对BLM处理的存活程度不同：当作为悬浮液中的单细胞处理时，先前的“外层”细胞比“内层”细胞受影响小。然而，在完整球体中，发现随着距外缘距离增加细胞抗性逐渐增强。
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